http://utah.technologypublisher.comBe the first to know about the latest inventions and technologies available from University of Utahen-USThu, 29 Jul 2010 13:21:36 GMTFri, 16 Jul 2010 08:15:54 GMThttp://blogs.law.harvard.edu/tech/rssdenise@tco.utah.eduCopyright 2010, University of Utahhttp://utah.technologypublisher.com/technology/5486Invention SummaryDuring organ transplantation and routine cardiac surgery, the duration of time an organ is outside the body may be lengthy. A storage solution is used to preserve the functional and anatomical integrity of the heart or other organs. This invention discloses a novel solution for preservation of heart and lung for use in both organ transplantation and protection of the heart in cardiac surgery. Market ApplicationsThe rapidly growing tissue and organ transplantation market, which recently topped 1 million procedures in a year worldwide, is on the cusp of even more dramat...Fri, 16 Jul 2010 08:15:54 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/5486http://utah.technologypublisher.com/technology/5485Invention SummaryA set of human plasma, serum, urine and DNA samples along with some limited clinical data collected since 1978 for the study of the genetics of atherosclerosis, dyslipidemias, hypertension and other chronic disease, some samples are from patients having obesity or who are markedly thin. Large and well-characterized kindreds have been well studied and samples have been collected for over 29 years. Market ApplicationsThis sample and data set may be licensed for use as a research tool. Individual samples are associated with consent forms that may limit their use, so not a...Fri, 16 Jul 2010 08:15:53 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/5485http://utah.technologypublisher.com/technology/5369Summary: The invention integrates imaging technology with drug delivery technology to form a new technology platform: Therapeutic MRI. Novel fluorinated (19F) imaging tracers known as 19FIT produce a MRI signal without tissue background interference and are proven safe and rapidly excreted in mice. The general structure of the 19FIT molecule is a water-soluble asymmetric fluorinated dendrimer. Conjugation of 19FIT to a drug molecule results in a prodrug with dual imaging and therapeutic functions. The concentration of 19FIT is directly proportional to the MRI signal intensity. This te...Wed, 30 Jun 2010 09:36:20 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/5369http://utah.technologypublisher.com/technology/5310Tue, 15 Jun 2010 10:23:06 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/5310http://utah.technologypublisher.com/technology/5301Fri, 11 Jun 2010 09:43:47 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/5301http://utah.technologypublisher.com/technology/5145Fri, 07 May 2010 10:53:55 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/5145http://utah.technologypublisher.com/technology/4876Thu, 01 Apr 2010 09:16:58 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4876http://utah.technologypublisher.com/technology/4875Thu, 01 Apr 2010 09:16:58 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4875http://utah.technologypublisher.com/technology/4868Wed, 31 Mar 2010 08:25:33 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4868http://utah.technologypublisher.com/technology/4547Mon, 08 Feb 2010 10:11:03 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4547http://utah.technologypublisher.com/technology/4546Fri, 05 Feb 2010 12:59:57 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4546http://utah.technologypublisher.com/technology/4364Fri, 18 Dec 2009 14:19:00 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4364http://utah.technologypublisher.com/technology/4319Mon, 14 Dec 2009 17:35:45 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4319http://utah.technologypublisher.com/technology/4318Mon, 14 Dec 2009 17:35:44 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4318http://utah.technologypublisher.com/technology/4317Mon, 14 Dec 2009 17:35:44 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4317http://utah.technologypublisher.com/technology/4316Invention SummaryThe technology in this invention is a minimally invasive procedure for image-guided cancer treatment using contrast-enhanced MRI with photodynamic therapy. The technology includes the administration of MRI contrast-agent-labeled polymer-photosensitizer conjugates, detection of cancer tissues with contrast enhanced MRI and illumination of those tissues with a laser of a certain wavelength. This specific irradiation will activate the photosensitizer accumulated in the tumor or cancer tissue, resulting in cancer cell death. This is an effective treatment to cancer tissues ...Mon, 14 Dec 2009 17:35:43 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4316http://utah.technologypublisher.com/technology/4315Invention Summary Recent advances in technology have led to methods for generating large sets of genomic and proteomic samples. This has created a need for tools that facilitate rapid screening and analysis of these large sets of samples. Immobilization of proteins and nucleic acids on a solid phase is a useful way to perform separation of biomolecules, screen for enzymatic activity, or interrogate for binding events. However, immobilization of macromolecules on a membrane surface with maximum retention of their activity and structural integrity still presents a challenge. Direct covalent a...Mon, 14 Dec 2009 17:35:43 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4315http://utah.technologypublisher.com/technology/4314Invention SummaryAcute Renal Failure (ARF), in the context of multi-organ failure and in high risk patients, remains a common, and often fatal (~50% mortality), complication. Preventative measures are only poorly effective, and dialysis therapy is expensive and time consuming. ARF is characterized by cell injury and death by necrosis and apoptosis in the tubular epithelium. Consequently, recovery from ARF depends on the reestablishment of cells in the damaged area via processes that require surviving cells to both proliferate and migrate into the sites of injury. While growth factors su...Mon, 14 Dec 2009 17:35:42 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4314http://utah.technologypublisher.com/technology/4313Invention Summary Market Applications Features and Benefits IP Status Related Research Mon, 14 Dec 2009 17:35:42 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4313http://utah.technologypublisher.com/technology/4312Mon, 14 Dec 2009 17:35:42 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4312http://utah.technologypublisher.com/technology/4311Mon, 14 Dec 2009 17:35:41 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4311http://utah.technologypublisher.com/technology/4310Mon, 14 Dec 2009 17:35:41 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4310http://utah.technologypublisher.com/technology/4309Invention SummaryIncreasing the concentration of cells and microorganisms by filtration for solid phase imaging and counting is a rapid, sensitive tool. In addition, filtration is used for purification of genomic DNA from biological samples, which is a requisite initial step in the conducting many molecular diagnostic assays. Fluorescent analysis of these small particles directly on the filtration membrane without a transfer step would increase efficiency and reduce cost. However, this is typically limited by membrane autofluorescence. The aluminum oxide-based membrane (AOM), Anopore¿ ...Mon, 14 Dec 2009 17:35:40 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4309http://utah.technologypublisher.com/technology/4308Invention SummaryIn healthy individuals, bone resorption and formation are well balanced, with the bone mass maintained in a steady state. Disturbance of such balance may lead to a number of bone diseases such as osteoporosis, Paget¿s disease, osteoporosis and bone cancer. With the worldwide prevalence of osteoporosis alone estimated at approximately 96 million people in 2004, there is increasing need for effective therapeutics to delay bone disease progression, reverse disease effects, and improve the quality of life for patients. However, most current therapeutics for these diseases a...Mon, 14 Dec 2009 17:35:40 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4308http://utah.technologypublisher.com/technology/4307Invention Summary Cancer is the second leading cause of death by disease in the U.S. It is essential to develop anticancer agents that demonstrate good efficacy without causing systemic toxicity. The cytotoxicity of anticancer agents can be increased by targeting them specifically to the tumor cells. It can be further augmented by directing the anticancer agent to specific subcellular compartments where the drug exerts its action. Dr. Kopecek and colleagues have created a system where drugs are first passively targeted to tumor cells based on conjugation with polymers through a degradable l...Mon, 14 Dec 2009 17:35:39 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4307http://utah.technologypublisher.com/technology/4306Invention SummaryMarket ApplicationsFeatures and BenefitsIP StatusRelated ResearchMon, 14 Dec 2009 17:35:39 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4306http://utah.technologypublisher.com/technology/4305Invention SummaryFebrile seizures are the most common seizure disorder of infancy with a prevalence of 2-5% in European and North American infants. The impact of seizures brought on by elevated body temperature is considerable because individuals who experience them have a 2-7% incidence of developing afebrile seizures and epilepsy later in life. This technology implicates mutations in the sodium channel gene scn9a (nav1.7) in familial and sporadic cases of febrile convulsions and its associated severe complications such as idiopathic generalized epilepsy and intractable epilepsy. It is...Mon, 14 Dec 2009 17:35:39 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4305http://utah.technologypublisher.com/technology/4304Invention Summary There are more than 750,000 tissue and body-part transplants conducted annually, according to the American Association of Tissue Banks. There are many applications that utilize skin grafting: reconstruction after surgery; tissue replacement in burn victims and patients with epidermolysis bullosa (EB); treatment of chronic ulcers; and hair restoration to areas of alopecia. Fresh skin can only be stored for 7 days before cryopreservation is required. As such, most skin transplanted in the U.S. is suboptimal frozen tissue. Availability of higher quality viable tissue would res...Mon, 14 Dec 2009 17:35:38 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4304http://utah.technologypublisher.com/technology/4303Invention Summary The technology in this invention is a water-soluble polymeric drug delivery system for the improved treatment of rheumatoid arthritis and other inflammatory diseases. The delivery system consists of a water-soluble polymer backbone, targeting moieties, and antirheumatic drugs. The polymeric background and the targeting moieties would direct the delivery system specifically to the disease lesions. The uniquely designed linkages that connect the drug to the polymer backbone will be cleaved specifically at the lesions to release the drug. Due to the strong tissue specificity...Mon, 14 Dec 2009 17:35:38 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4303http://utah.technologypublisher.com/technology/4302Invention SummaryPresent-day drug discovery frequently involves screening hundreds of thousands of compounds for biological activity against a target molecule. Compound screening is typically preformed using cell-based systems because they promise accurate, whole-cell data representative of the physiological condition. However, compounds that pass this initial screening often fail in future toxicological testing. Pharmaceutical companies want the closest possible model to the human organism while still retaining the ability to look at several thousand samples quickly and efficiently. Fl...Mon, 14 Dec 2009 17:35:37 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4302http://utah.technologypublisher.com/technology/4301Invention Summary Market Applications Features and Benefits IP Status Related Research Mon, 14 Dec 2009 17:35:37 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4301http://utah.technologypublisher.com/technology/4300Invention Summary The present invention provides a novel method to use alkylaryl polyether alcohol polymers as antioxidants to block oxidant reactions and prevent tissue injury and disease that are related to overproduction of partially reduced dioxygen (O2) species, such as chronic pulmonary inflammation, myocardial infarction and stroke, adult respiratory distress syndrome, and oxygen toxicity of the lung. This invention shows that by inhibiting the activation of nuclear transcription factor NF-?B, alkylaryl polyether alcohol polymers can inhibit the cellular production of pro-inflammatory c...Mon, 14 Dec 2009 17:35:37 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4300http://utah.technologypublisher.com/technology/4299Invention Summary The present invention provides a method for suppressing malignant melanoma proliferation by inhibiting NAD(P)H oxidase enzymes from generating reactive oxygen species (ROS). Malignant melanoma cells spontaneously generate ROS that promote constitutive activation of the transcription factor nuclear factor-kB (NF-kB), which in turn activates cell proliferation. This invention showed that melanoma proliferation was reduced by inhibiting the function of NAD(P)H oxidase and production of its ROS signaling products. It also showed that the generation of intracellular ROS in mela...Mon, 14 Dec 2009 17:35:36 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4299http://utah.technologypublisher.com/technology/4298Invention SummaryThough oxidative stress is widely implicated in pathogenic states including aging and heart failure, the role of reductive stress, which is defined as the abnormal increase of reducing equivalents (e.g., glutathione, NADPH), remains controversial. The present invention provides genetic, molecular, and biochemical evidence for showing the role of reductive stress in mammals, and proposes novel and, potentially personalized, therapeutic strategies to use anti-reductants for the treatment of human diseases such as heart failure, diabetes mellitus, and degenerative diseases. Anti-...Mon, 14 Dec 2009 17:35:36 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4298http://utah.technologypublisher.com/technology/4297Invention SummaryThe present invention provides the first and only genetic mouse model of synovial sarcoma, a highly aggressive, malignant childhood/young adult soft tissue cancer. This mouse model was generated by conditionally expressing the human SYT-SSX2 fusion protein with myoblasts. It faithfully recapitulates human synovial sarcoma in presentation, histopathology, molecular markers, immunohistochemistry and transcriptional profile. Market ApplicationsCurrently, the origin and pathogenesis of synovial sarcoma is poorly understood and patients¿ response to existing therapeutic mod...Mon, 14 Dec 2009 17:35:35 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4297http://utah.technologypublisher.com/technology/4252Thu, 10 Dec 2009 10:37:22 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4252http://utah.technologypublisher.com/technology/4251Thu, 10 Dec 2009 10:37:19 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4251http://utah.technologypublisher.com/technology/3538Invention SummaryThis invention discloses a novel set of interactions between the prostaglandin and purine signaling pathways that reveal a new class of drug targets for future NDI therapies. Market ApplicationsNephrogenic Diabetes Insipidus (NDI) can be acquired as a result of the use of medicines such as lithium for bipolar disorders, or others such as cisplatin, puromycin, adriamycin, calcium channel blockers, and amphotericin B. Conditions such as chronic kidney disease, electrolyte disorders (high calcium or low potassium levels in the blood), ureteral obstruction (prostatic hyper...Wed, 21 Oct 2009 13:16:44 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3538http://utah.technologypublisher.com/technology/3537Invention SummaryThis invention discloses an approach whereby the administration of a synthetic organic compound specifically induces proliferation of erythropoietin-producing peritubular interstitial cells in the kidney, which results in increased synthesis of erythropoietin. After cessation of treatment with the synthetic compound, there is persistence of EPO-producing peritubular interstitial cells in the kidney. Preliminary studies revealed that this approach had no adverse effect on kidney function. To the best of the inventors¿ knowledge, this is the first model where such a strik...Wed, 21 Oct 2009 13:16:44 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3537http://utah.technologypublisher.com/technology/3536Wed, 21 Oct 2009 13:10:24 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3536http://utah.technologypublisher.com/technology/3535Wed, 21 Oct 2009 13:10:23 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3535http://utah.technologypublisher.com/technology/3534Wed, 21 Oct 2009 13:10:23 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3534http://utah.technologypublisher.com/technology/3533Wed, 21 Oct 2009 13:10:23 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3533http://utah.technologypublisher.com/technology/3532Wed, 21 Oct 2009 13:10:22 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3532http://utah.technologypublisher.com/technology/3531Wed, 21 Oct 2009 13:10:21 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3531http://utah.technologypublisher.com/technology/3530Wed, 21 Oct 2009 13:10:21 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3530http://utah.technologypublisher.com/technology/3529Reference Number: U-4123 Invention Description: Until recently, the general belief was that water diffused so quickly across biological membranes that the water inside of a cell would be isotopically indistinguishable from the isotope ratio of extracellular water. This technology provides an avenue of testing this assumption using stable isotope ratio mass spectrometry. Research done as part of this technology has indicated that this commonly held assumption is not correct in bacterial and mammalian cells. Data collected has shown that cells that are metabolizing more rapidly have...Wed, 21 Oct 2009 12:32:05 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3529http://utah.technologypublisher.com/technology/3528Reference Number: U-3856 Invention Description: This invention identifies the human Penumbra gene nucleic acid molecules, proteins encoded by these nucleic acid molecules, antibodies raised against these proteins, and inhibitors of these proteins. The invention also includes methods of using these molecules in the detection of disease, including human myeloid malignancies. Penumbra (a contraction of proerythroblast 'nu' and membrane) is a newly discovered member of the tetraspanin family, a distinct group of four-domain transmembrane proteins that appear to organize other proteins...Wed, 21 Oct 2009 12:32:03 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3528http://utah.technologypublisher.com/technology/3527Wed, 21 Oct 2009 12:32:03 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3527http://utah.technologypublisher.com/technology/3526Wed, 21 Oct 2009 12:32:01 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3526http://utah.technologypublisher.com/technology/3525Wed, 21 Oct 2009 12:31:57 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3525http://utah.technologypublisher.com/technology/3524Wed, 21 Oct 2009 12:31:56 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3524http://utah.technologypublisher.com/technology/3523Reference Number: U-4089 Invention Description: The present invention provides a new family of potent D-peptide inhibitors of HIV entry. These inhibitors have several advantages over Fuzeon, the only FDA-approved HIV entry inhibitor that is currently available. First, these inhibitors are resistant to proteases (potentially allowing oral bioavailability, long serum half-life, long shelf-life, infrequent dosing, and use as a microbicide); secondly, they target a highly conserved region of HIV that has been shown to be critical for viral infectivity, reducing the likelihood of resis...Wed, 21 Oct 2009 12:31:53 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3523http://utah.technologypublisher.com/technology/3522Wed, 21 Oct 2009 12:31:53 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3522http://utah.technologypublisher.com/technology/3521We are currently working on a non-confidential summary for this technology. For more information please contact: Denise Bertsch denise@tco.utah.edu (801)213-3564 Wed, 21 Oct 2009 12:31:50 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3521http://utah.technologypublisher.com/technology/3520Invention SummaryPremature stop codon and framshift mutations account for approximately 25% of all cases of genetic disease. Unfortunately, therapeutic approaches to diseases caused by frameshift and nonsense mutations have been very limited and difficult to implement; as such, there is a need for a method of treating such mutations/diseases. This invention is designed to suppress the phenotypic effects of such mutations by manipulating the process of protein synthesis. Exposing an mRNA to morpholino antisense oligonucleotides can result in ribosomal frame shift. A ribosomal frameshift ...Wed, 21 Oct 2009 12:31:47 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3520http://utah.technologypublisher.com/technology/3519Wed, 21 Oct 2009 12:31:46 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3519http://utah.technologypublisher.com/technology/3518Wed, 21 Oct 2009 12:31:45 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3518http://utah.technologypublisher.com/technology/3489Mon, 05 Oct 2009 10:15:22 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3489http://utah.technologypublisher.com/technology/3479Wed, 30 Sep 2009 08:18:47 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3479http://utah.technologypublisher.com/technology/3477Wed, 30 Sep 2009 08:17:40 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3477http://utah.technologypublisher.com/technology/3476Wed, 30 Sep 2009 08:17:38 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3476http://utah.technologypublisher.com/technology/3459Fri, 25 Sep 2009 11:32:42 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3459http://utah.technologypublisher.com/technology/3458Fri, 25 Sep 2009 11:32:40 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3458http://utah.technologypublisher.com/technology/3456Fri, 25 Sep 2009 10:15:02 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3456http://utah.technologypublisher.com/technology/3455Fri, 25 Sep 2009 08:57:22 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3455http://utah.technologypublisher.com/technology/3454Fri, 25 Sep 2009 08:57:20 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3454http://utah.technologypublisher.com/technology/3453Fri, 25 Sep 2009 08:57:19 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3453http://utah.technologypublisher.com/technology/3452Fri, 25 Sep 2009 08:57:11 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3452http://utah.technologypublisher.com/technology/3451Fri, 25 Sep 2009 08:57:06 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3451http://utah.technologypublisher.com/technology/3449Fri, 25 Sep 2009 08:57:01 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3449http://utah.technologypublisher.com/technology/3448Fri, 25 Sep 2009 08:56:32 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3448http://utah.technologypublisher.com/technology/3401Wed, 02 Sep 2009 09:04:24 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3401http://utah.technologypublisher.com/technology/3400Wed, 02 Sep 2009 09:04:23 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3400http://utah.technologypublisher.com/technology/3399Invention SummaryEpilepsy, first recorded by the Babylonians several thousand years ago, is a neurological disorder characterized by recurrent, transient seizures caused by a disturbance in the electrical activity of the central nervous system. Epilepsy is a common neurological disorder that affects 2.7 million people in the U.S. According to the CDC, 10% of U.S. citizens experience a seizure in their lifetime, and 3% of the general population will have a diagnosis of epilepsy by the age of 75. An additional 181,000 new patients are diagnosed each year in the U.S. Of those diagnosed wit...Wed, 02 Sep 2009 09:04:23 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3399http://utah.technologypublisher.com/technology/3377Thu, 27 Aug 2009 15:05:29 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3377http://utah.technologypublisher.com/technology/3375Thu, 27 Aug 2009 15:05:27 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3375http://utah.technologypublisher.com/technology/3374Thu, 27 Aug 2009 15:05:26 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3374http://utah.technologypublisher.com/technology/3373Thu, 27 Aug 2009 15:05:26 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3373http://utah.technologypublisher.com/technology/3372Thu, 27 Aug 2009 15:05:25 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3372http://utah.technologypublisher.com/technology/3371Thu, 27 Aug 2009 15:05:24 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3371http://utah.technologypublisher.com/technology/3369Thu, 27 Aug 2009 15:05:23 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3369http://utah.technologypublisher.com/technology/3368Thu, 27 Aug 2009 15:05:23 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3368http://utah.technologypublisher.com/technology/3367Thu, 27 Aug 2009 15:05:22 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3367http://utah.technologypublisher.com/technology/3308Mon, 17 Aug 2009 08:42:29 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3308http://utah.technologypublisher.com/technology/3307Mon, 17 Aug 2009 08:42:29 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3307http://utah.technologypublisher.com/technology/3306Mon, 17 Aug 2009 08:42:29 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3306http://utah.technologypublisher.com/technology/3305Mon, 17 Aug 2009 08:42:28 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3305http://utah.technologypublisher.com/technology/3304Mon, 17 Aug 2009 08:42:28 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3304http://utah.technologypublisher.com/technology/3303Mon, 17 Aug 2009 08:42:27 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3303http://utah.technologypublisher.com/technology/3302Mon, 17 Aug 2009 08:42:27 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3302http://utah.technologypublisher.com/technology/3301Mon, 17 Aug 2009 08:42:26 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3301http://utah.technologypublisher.com/technology/3300Mon, 17 Aug 2009 08:42:26 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3300http://utah.technologypublisher.com/technology/3299Mon, 17 Aug 2009 08:42:25 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3299http://utah.technologypublisher.com/technology/3298Mon, 17 Aug 2009 08:42:24 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3298http://utah.technologypublisher.com/technology/3296Mon, 17 Aug 2009 08:42:23 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3296http://utah.technologypublisher.com/technology/3295Mon, 17 Aug 2009 08:42:22 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3295http://utah.technologypublisher.com/technology/3209Tue, 21 Jul 2009 10:52:24 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3209http://utah.technologypublisher.com/technology/3208Tue, 21 Jul 2009 10:52:24 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3208http://utah.technologypublisher.com/technology/3207Tue, 21 Jul 2009 10:52:23 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3207http://utah.technologypublisher.com/technology/3206Tue, 21 Jul 2009 10:52:22 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3206http://utah.technologypublisher.com/technology/3205Tue, 21 Jul 2009 10:52:21 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3205http://utah.technologypublisher.com/technology/3204Tue, 21 Jul 2009 10:52:19 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3204http://utah.technologypublisher.com/technology/3203Tue, 21 Jul 2009 10:52:19 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3203http://utah.technologypublisher.com/technology/3043Invention SummaryA program for identifying families at risk for a variety of chronic diseases was implemented in Utah in 1983 and has continued through 2006 using a paper-based data collection, resulting in more than 1 Million entries from 150,000 families. The investigators are now implementing a web-based tool which can be used as part of a genetics educational package throughout the United States. Although the software is designed for use by secondary education classes, it can also be developed for use by any health care provider or for anyone wishing to study their genealogical records and...Wed, 17 Jun 2009 12:48:43 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3043http://utah.technologypublisher.com/technology/3042Invention SummaryThis invention reflects the discovery and structure of the KCNQ2 and KCNQ3 potassium channels (previously known as KVEBN1 and KVEBN2, respectively), which are associated with the BFNC disorder. Several cases had KCNQ2 mutations including three missense mutations, three frameshifts, two nonsense mutations, and one splice site mutation. Gene KCNQ3 was found in a separate case in which the mutation had been localized to chromosome 8. This invention indicates that potassium-channel defects can lead various forms of early-onset epilepsies including not only BFNC but also juvenile m...Wed, 17 Jun 2009 12:48:39 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/3042http://utah.technologypublisher.com/technology/2651Thu, 28 May 2009 16:40:14 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/2651http://utah.technologypublisher.com/technology/2650Thu, 28 May 2009 16:40:12 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/2650http://utah.technologypublisher.com/technology/2648Thu, 28 May 2009 16:10:21 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/2648http://utah.technologypublisher.com/technology/2647Thu, 28 May 2009 15:19:39 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/2647http://utah.technologypublisher.com/technology/1954Tue, 07 Apr 2009 14:34:52 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1954http://utah.technologypublisher.com/technology/1910This invention defines a valuable system for a wide range of clinical diagnostics, including the determination of analyte concentration. The invention comprises an optical detection system that detects fluorescence from fluorescent binding assays in a planar waveguide biosensor. This patented, optical biosensor yields rapid, quantitative, and highly sensitive and specific assays of one or more numerous analytes simultaneously in one disposable cartridge. The biosensor¿s planar form allows the immobilization of protein capture antibodies or oligonucleotide capture probes on the biosensor surfac...Thu, 02 Apr 2009 15:52:50 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1910http://utah.technologypublisher.com/technology/1895Invention SummaryThe development of effective drugs remains a challenging, risky and expensive endeavor. Currently it takes an estimated 7-10 years to develop and market a drug at a cost that exceeds $800 million. In addition, advances in combinational chemistry are resulting in a large supply of chemical compounds that need to be screened for their efficacy in fighting disease. However, high-throughput drug screening (HTS) is emerging in the field as pharmaceuticals and biotechnology companies compete to become the first to market new drugs. Being able to rapidly screen libraries of compounds...Tue, 31 Mar 2009 15:05:04 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1895http://utah.technologypublisher.com/technology/1894Tue, 31 Mar 2009 15:05:01 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1894http://utah.technologypublisher.com/technology/1504Invention Summary Security inspection of luggage in airports is conducted using X-ray screening machines. The same machines cannot be used for passenger inspection because of the harmful nature of the X-rays towards human bodies when exposed frequently. Passenger screening is done using simple induction devices that respond to the presence of metal objects. This technology describes a novel method of security screening and inspection of passengers using a broadband electromagnetic imaging technique. It is made possible by a set of transmitters and receivers that are placed on the sidewalls, ce...Tue, 03 Mar 2009 14:19:50 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1504http://utah.technologypublisher.com/technology/1503Tue, 03 Mar 2009 14:19:49 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1503http://utah.technologypublisher.com/technology/1501Invention Summary This invention encapsulates a powerful method for segmenting CT- or MRI-imaged vessels and other structures. The invention employs the principle of continuity in a maximum intensity projection (MIP) algorithm of the depth buffer (Z-buffer), a two-dimensional matrix representing the surface of a three-dimensional object. This enhancement process, or depth buffer segmentation (DBS), segments an image volume into regions having a likelihood of vessel occupation and regions that are unlikely to contain vessels. DBS merges the global properties of the MIP process with the loc...Tue, 03 Mar 2009 14:19:48 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1501http://utah.technologypublisher.com/technology/1500Invention Summary The market for nanosize powders is large and diverse, ranging from environmental cleanup to chemical and petroleum industries. The conventional methods for molecular synthesis face two specific problems. First, the formation of fine uniform size particles. This requires a good control over the nucleation and the growth of particles that makes the manufacture of such particles in bulk quantities impractical or impossible. The second problem is the agglomeration of particles. This invention describes a method to synthesize nanosize powders that have a reduced tendency to agglom...Tue, 03 Mar 2009 14:19:47 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1500http://utah.technologypublisher.com/technology/1499Invention Summary Digital image enhancement and sharpening is widely used in biomedical, geophysical astronomical, high definition television, remote sensing and other industrial applications. The current methods of digital enhancement of images are not effective since they are based on a mathematical algorithm that has an unstable and non-unique solution. This invention describes a new method of digital enhancement and sharpening that is based on specially selected constraints to reconstruct the sharp original image. This method uses a new form of a constraint to minimize the area where stron...Tue, 03 Mar 2009 14:19:47 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1499http://utah.technologypublisher.com/technology/1498Tue, 03 Mar 2009 14:19:46 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1498http://utah.technologypublisher.com/technology/1497Invention Summary The electrical properties of cells, organelles, and protein solutions are of fundamental interest in the fields of biophysics, physiology, biotechnology, and medicine. This invention relates to detector systems for measurement of the electrical characteristics of liquids, gases and biological materials. Previously used methods are disadvantageous as they are either invasive or require a priori models describing the cell. This invention can be incorporated onto the same chip as the micro-analysis system and results in increased resolution. Market Applications A micro-electric ...Tue, 03 Mar 2009 14:19:46 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1497http://utah.technologypublisher.com/technology/1496Tue, 03 Mar 2009 14:19:45 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1496http://utah.technologypublisher.com/technology/1495 Reference Number: U-3411 Invention Description: Polyethylenimine (PEI) has long been used as a carrier for non-viral gene delivery; however, its molecular weight and geometry have not been optimized for gene delivery. Existing gene carriers though suitable for limited purposes fail to have an overall utility for gene delivery due to certain inherent deficiencies. This invention describes a modification of linear polyethylenimine with cholesterol conjugates to form three compounds with different geometries- linear (L-shaped), T-shaped, or L and T shaped. These modified Linear Polyet...Tue, 03 Mar 2009 14:19:45 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1495http://utah.technologypublisher.com/technology/1494Invention Summary The invention is a platform for single molecule chemical and biological detection using chemically or genetically engineered protein ion channels. A single pore is fabricated in a thin glass membrane at the end of a glass capillary. The orifice of the pore can be varied between 5 and 100 nm. The membrane/pore structure is employed as a solid support for a lipid bilayer membrane, into which the protein ion channel is inserted. Electrodes placed on either side of the membrane are used to monitor the current through the pore in response to analyte binding to protein receptors. M...Tue, 03 Mar 2009 14:19:44 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1494http://utah.technologypublisher.com/technology/1493Tue, 03 Mar 2009 14:19:43 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1493http://utah.technologypublisher.com/technology/1492Invention Summary The technology offers a robust and feasible image reconstruction method for sensitivity encoded MRI. The new method is an autocalibrating technique based on the fact that coil sensitivity profiles have limited support in k-space domain. GARSE exploits all data dimensions to calculated reconstruction coefficients. Market Applications Sensitivity encoded MRI has recently become the method to speed up data acquisition; it reduces image artifacts and improve temporal resolution. This novel technology developed at the University of Utah can be used in all sensitivity encoded M...Tue, 03 Mar 2009 14:19:41 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1492http://utah.technologypublisher.com/technology/1491Invention Summary University of Utah researchers have developed an exciting new device and method for supporting and positioning the human head and neck for repeatable MR imaging. This device is especially useful for repositioning the head for carotid artery studies where even a small difference in head position can render imaging results useless. The new device can be used for ANY imaging application where repeatable positioning is important. This device allows the patient to be repeatedly positioned for imaging within a 1-2 mm tolerance. The device also allows the user to easily repositio...Tue, 03 Mar 2009 14:19:41 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1491http://utah.technologypublisher.com/technology/1490Invention Summary The present invention provides a non-viral terplex gene delivery system for delivering exogenous genetic material (DNA or RNA) efficiently and safely into target cells. The system comprises a hydrophobized, positively charged, biocompatible polymer; a lipoprotein; and a selected nucleic acid. Hydrophobic and electrostatic interactions between the components provide for the formation of the condensed DNA-containing complex. This system can efficiently deliver plasmids and oligonucleotides into the host cells. Market Applications Success in gene therapy largely depends upon th...Tue, 03 Mar 2009 14:19:40 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1490http://utah.technologypublisher.com/technology/1489Invention Summary Despite recent progress in biotechnology, two problems continue to hinder the use of biological macromolecules in medicine and industry: their molecular stability and sensitivity to chemical and physical stresses during manufacture, storage and delivery; and a rate of release that is consistent with the needs of the patient. The currently available solutions seem to be mutually exclusive, solving one problem but not both. Covalent attachment of polyethylene glycol (PEG) to the macromolecule greatly aids stability but can cause a decrease in bioactivity depending on the conj...Tue, 03 Mar 2009 14:19:40 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1489http://utah.technologypublisher.com/technology/1488Tue, 03 Mar 2009 14:19:39 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1488http://utah.technologypublisher.com/technology/1486Tue, 03 Mar 2009 14:19:38 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1486http://utah.technologypublisher.com/technology/1485Invention Summary This technology is an innovative process which utilizes titanium-monobromide (TiB) in generating a hard surface coating. During the process, TiB whiskers are formed on the subjected components surface. This technology possesses clear advantages over other coatings, such as the ability to be applied to complex parts, due to the simplicity of the coating process. Preliminary research yielded information that shows TiB whisker coatings can make titanium surfaces harder by as much as three times the hardness of regular, uncoated titanium. These results also suggest that the we...Tue, 03 Mar 2009 14:19:19 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1485http://utah.technologypublisher.com/technology/1484Invention Summary Technology for X-ray detection in cone-beam geometry is rapidly improving and offers more and more potential for the construction of robust computed tomography systems for high-resolution volume imaging. In order to optimally build such systems, problem of cone-beam image reconstruction needs to be understood. Our technology consists of a new methodology for reconstructing images from cone-beam projection data. This methodology facilitates exact reconstruction with limited measurements and does not require as much data as other known methods in order to produce high qualit...Tue, 03 Mar 2009 14:19:16 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1484http://utah.technologypublisher.com/technology/1483Tue, 03 Mar 2009 14:19:12 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1483http://utah.technologypublisher.com/technology/1481Invention SummaryBorides are hard ceramic engineered materials that possess high strength and hardness in addition to resisting high temperature oxidation and corrosive chemicals. Our technology consists of a method for manufacturing nanostructured Titanium Monoboride (containing more than 80% Titanium monoboride whiskers, 20% Ti and no TiB2) that possesses high flexural and mechanical strength. Market ApplicationsThere is a need for materials which have very high strength and hardness, are machinable, cheap and easy to manufacture. Current methods of producing these materials are eith...Tue, 03 Mar 2009 14:18:32 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1481http://utah.technologypublisher.com/technology/1479Invention SummaryA miniaturized telemetry coil is proposed which will be manufactured from copper, gold or platinum and deposited on high magnetic permeability material. This will allow the delivery of power required for the operation of micro electronic circuitry and neural array implanted inside the body. The high permeability material will intensify the magnetic field in the vicinity of the coil and thus will enhance the efficiency of power transmission. Market ApplicationsState of the art micro scale thin film coils feature permeability of µ = 3-10 at best. Low Temperature Co-fired...Tue, 03 Mar 2009 14:18:31 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1479http://utah.technologypublisher.com/technology/1478Invention SummaryThe invention is an electrochemical sensor comprising of a Pt microdisk electrode sealed to the bottom of a conical-shaped pore in glass. The orifice of the pore can be varied between 5 and 100 nm. The device is employed as a sensor for detection of chemical and biological molecules by measuring the change in the conductance of the pore upon binding for the analyte to receptor groups chemically or physically attached at the interior pore wall. Market ApplicationsThere is an intense interest in the development of chemical and biological sensors based on selective transp...Tue, 03 Mar 2009 14:18:30 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1478http://utah.technologypublisher.com/technology/1477Invention Summary Nanoparticles passing through a pore are readily detected by measuring the transient change in the electrical resistance of the pore. This method can be used to determine the concentration of the particles in a solution, as well as the size and electrical charge of the particle. This invention discloses the development and working of a device, a glass nanopore particle analyzer that can be used to measure particle concentration in a solution. The developed method can be used to synthesize a nanopore, with radius as small as 5 nm, in a glass membrane. Market Applications The ...Tue, 03 Mar 2009 14:18:23 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1477http://utah.technologypublisher.com/technology/1476Tue, 03 Mar 2009 14:18:19 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1476http://utah.technologypublisher.com/technology/1475Tue, 03 Mar 2009 14:18:03 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1475http://utah.technologypublisher.com/technology/1473Invention SummaryThis invention describes novel soluble steroidal peptides designed for gene delivery. These peptides are endowed with several desirable characteristics including water solubility, biodegradability, amphiphilicity, enhanced membrane interactions, endosomal release and potential nuclear targeting. The head group of SSP was derived from FDA approved human protamine-2 whose sequence was modified. SSP was found not to have any significant secondary structure. Membrane permeabilization studies showed that SSP, in a pH dependent fashion increased the diffusion of ethidium bro...Tue, 03 Mar 2009 14:17:45 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1473http://utah.technologypublisher.com/technology/1265Invention Summary The methods of quantitative analysis of microarray experiments are bound to end-point acquisitions, which is not suited for obtaining reliable quantifications because of the problems with changing (and often low) signal-to-noise ratios. This invention describes a device to acquire real-time melting data for double-stranded nucleic acids, immobilized on the solid supports, and a novel method of quantification of nucleic acids by applying algorithms based on thermodynamic or kinetic models of association and dissociation of double-stranded nucleic acids. Market Applications Th...Tue, 24 Feb 2009 09:33:52 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1265http://utah.technologypublisher.com/technology/1264Invention Summary This invention improves the performance of parallel-acquisition-enhanced dynamic imaging by using the temporal correlations between an under sampled frame (acquired under parallel imaging) and a previously acquired fully sampled reference frame. This technique, deemed K-space inherited parallel acquisition (KIPA) imaging, is based on the assumption that the localized reconstruction coefficients can be considered constant for all of the frames in a dynamic sequence. The KIPA scheme consists of acquiring one or more complete data sets for the first time frame and highly reduce...Tue, 24 Feb 2009 09:33:49 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1264http://utah.technologypublisher.com/technology/1263Invention Summary This invention consists of a SPECT system containing a collimator plate with one vertical slit followed by a second collimator plate with one or more "skewed' horizontal slits between the vertical-slit collimator and the detector. This skew-slit collimator system has the benefit of higher image magnification compared to conventional SPECT systems. The invention also includes a reconstruction algorithm for a high-sensitivity SPECT system with multiple-skew-slit imaging. This collimator and reconstruction system is ready to be implemented on current SPECT cameras for small-a...Tue, 24 Feb 2009 09:33:49 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1263http://utah.technologypublisher.com/technology/1262Invention Summary This invention defines several water-soluble additives to a proton exchange membrane fuel cells (PEMFC) electrode that contains precious metals. These additives lower the concentration of precious-metal ions in a solution and thereby suppress growth kinetics of the catalyst's particles. Under this invention, the additives include water-soluble nitrates, nitrites, sulfates, sulfites and chlorates, and halogen molecules. Market Applications In proton exchange membrane fuel cells (PEMFC), state-of-the-art anode and cathode catalysts contain particles of precious metals, typica...Tue, 24 Feb 2009 09:33:47 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1262http://utah.technologypublisher.com/technology/1261Invention SummaryThe technology presents two techniques to improve the spatial resolution, quality, and the accuracy of diffusion weighted (DWI) and diffusion-tensor MR imaging (DTI). Artifacts induced by susceptibility variations near the tissue interfaces and the subject's motion during data acquisition are the factors that limit the spatial resolution and clinical applicability of the above mentioned imaging techniques. The extent of susceptibility induced artifacts is directly related to the duration of echo planar (EPI) readouts ¿ longer readouts result in stronger artifacts. The ...Tue, 24 Feb 2009 09:33:46 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1261http://utah.technologypublisher.com/technology/1260Invention SummaryVascular endothelial growth factor (VEGF) is a primary stimulant for the development and maintenance of a vascular network in the vascularization of solid tumors. A powerful method for tumor regression is the blockade of VEGF-mediated angiogenesis. A naturally occurring biological strategy for inhibition of gene expression is RNA interference (RNAi). The technology describes a novel and simple system for the in vivo application of siRNA through Chol-R9 that can be used in cancer therapy. The synthesized Chol-R9 acts as a delivery vehicle for the local administration of ...Tue, 24 Feb 2009 09:33:43 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1260http://utah.technologypublisher.com/technology/1259Invention SummaryMineral exploration needs a reliable method to distinguish between uneconomic mineral deposits and economic mineralization. Our technology consists of a new geophysical technique for subsurface material characterization, mineral exploration and mineral discrimination. It detects induced polarization effects in electromagnetic data and uses surface geophysical observations to determine the parameters of the relaxation model. These parameters are ultimately used for the discrimination of different types of rock formation. Market ApplicationsCurrent techniques for obtaini...Tue, 24 Feb 2009 09:33:42 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1259http://utah.technologypublisher.com/technology/1258Invention SummaryThe Therapeutic Device Inserter (TDI) is a device designed to hold and spatially manipulate therapeutic devices, and insert them via a high-speed insertion mechanism into body tissues. The invention utilizes a novel inserter design, with vacuum controlled device release, which greatly facilitates spatial control and accurate positioning of the device to be released. The TDI offers enough range of controlled motion for effective use and can also be used for high precision device removal. Market ApplicationsTraditional device inserters have not been able to hold a device...Tue, 24 Feb 2009 09:33:40 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1258http://utah.technologypublisher.com/technology/1257Invention SummaryThermogelling biodegradable polymers have been excellent carrier systems for drug delivery applications. Several systems have been engineered to obtain an exquisite balance of hydrophilicity and hydrophobicity, which causes the unique phase transition from sol-to-gel at below body temperature. Control over the thermogelling properties of such polymers is highly desired. This invention describes a novel polymer which possesses thermogelling properties based on aliphatic modification of biodegradable tri-block copolymers. The biodegradable hydrophobic part of a PEG-based...Tue, 24 Feb 2009 09:33:38 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1257http://utah.technologypublisher.com/technology/1256Invention SummaryThis invention describes a catalyst with a (1 nm) shell of a precious metal (e.g., platinum) on a nanoparticle core of inert material. The shell is sufficiently thin to achieve a large surface area per unit mass of the metal, yet sufficiently thick so that the material behaves like bulk material. The invention also teaches a method for the fabrication of this core-shell catalyst with an overall particle size that is 2 to 4 nm. Market ApplicationsIn many electrochemical devices, most notably proton exchange membrane fuel cells (PEMFC), precious metals and alloys are use...Tue, 24 Feb 2009 09:33:06 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1256http://utah.technologypublisher.com/technology/1255Invention SummaryThe generation of image artifacts in areas of high contrast or discontinuities is one of the greatest limitations of linear image filtering. These anomalies occur in the form of oscillations and the ringing effect is known as Gibb's phenomenon. Our technology introduces a new filtering technique for the elimination of Gibb's phenomenon. This is done by partitioning the image, filtering the partitions separately and combining them in a non-linear manner. The resultant signal is satisfactorily filtered without any noticeable Gibbs artifacts. Market ApplicationsThis techn...Tue, 24 Feb 2009 09:32:59 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1255http://utah.technologypublisher.com/technology/1254Tue, 24 Feb 2009 09:32:56 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1254http://utah.technologypublisher.com/technology/1253Tue, 24 Feb 2009 09:32:55 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1253http://utah.technologypublisher.com/technology/1252Invention Summary This method performs surface based amplification with better speed and greater fidelity than solution-based methods such as PCR. Market Applications Companies which used chip-based microarrays and total analysis without necessity of PCR. Features and Benefits *This method overcomes inherent limitations of solution-based amplifications through confining reactions to the interfaces (surfaces), while taking advantage of limited mobility of one of several groups of analytes (primers, amplification products), while allowing unrestricted movement of other groups of analytes (enzyme...Tue, 24 Feb 2009 09:32:55 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1252http://utah.technologypublisher.com/technology/1215Invention SummaryAdapting medical simulation technology to allow on-demand access to high-quality training in managing pediatric arrests will depend on developing more cost-effective ways of providing realistic simulations and meaningful performance assessments to a large number of providers across geographic areas covered by hospital networks. As a step toward meeting this objective, this technology offers a consensus-based method of assessing learner performance in these simulations from surveys of nationally recognized content experts in Pediatric Advanced Life Support (PALS). Marke...Wed, 18 Feb 2009 14:46:20 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1215http://utah.technologypublisher.com/technology/1214Invention SummaryThough many PET tracers have been developed, utilization of the modality has been greatly hampered because only a single tracer could be imaged at a time. This technology is a methodology for rapid multi-tracer PET imaging, where multiple PET tracers are injected during a single scan, and images and imaging measures for each tracer can be recovered from a single cyclotron run. These rapid multi-tracer methodologies make imaging of multiple PET tracers practicable and reasonably convenient, opening the door to numerous multi-tracer imaging opportunities for clinical, res...Wed, 18 Feb 2009 14:46:20 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1214http://utah.technologypublisher.com/technology/1213Invention SummaryReducible poly(amido ethylenimine)s (SS-PAEI's) are a novel class of cationic nonviral gene carriers that take advantage of the redox potential between the intracellular and extracellular environment. Nucleotides are thereby released into the cytoplasm through a triggered mechanism. However, this reducibility is a hindrance in systemic delivery. This invention employs cleavable, hydrolysable, or bioreducible linkages to graft serum stabilizing molecules to the SS-PAEIs. This will allow for increased serum stability while exhibiting little if any effect on reducibility ...Wed, 18 Feb 2009 14:46:20 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1213http://utah.technologypublisher.com/technology/1212Invention SummaryNeural prosthetics have come a long way and have shown good benefits to individuals by using microelectrode arrays, like Utah Electrode Arrays (UEAs). In UEA, to decrease the impedance of the device and facilitate transfer of electrical charge from silicon probe to neural tissue, the electrode tips need to be de-encapsulated. Conventionally, this is done with Aluminum foil, which is pierced through with the electrodes to procure the desired exposure. The exposed part of electrode is plasma etched while the Aluminum foil acts as a mask and protects the rest of the electr...Wed, 18 Feb 2009 14:46:19 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1212http://utah.technologypublisher.com/technology/1211Invention SummaryDye-sensitized solar cells (DSSCs) have received considerable attention as a cost-effective alternative to conventional solar cells. However, a major efficiency limiting factor in current nanoparticle-based DSSCs is the trap-limited diffusion transport mechanism of electrons, a slow mechanism that limits the device efficiency, especially at longer wavelengths. In this invention a new version of the dye-sensitized cells has been developed in which the traditional electrode (nanoparticle film) is replaced by a specially designed ZnO electrode possessing an exotic "nanopl...Wed, 18 Feb 2009 14:46:19 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1211http://utah.technologypublisher.com/technology/1210Invention Summary State-of-the-art low magnetic field sensors tend to be bulky, costly, and suffer from a lack of accuracy and stability in measuring the relatively weak magnetic fields typical in geophysical applications. This technology is a new method to produce high accuracy, ultra-sensitive, lightweight, and compact magnetic sensors. It is based on room temperature application and low fabrication cost. The device enables ultra-sensitive magnetometer performance with nano-Tesla (nT) resolution and is designed to achieve femto-second resolution for spin kinetic in organic media, which provi...Wed, 18 Feb 2009 14:46:19 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1210http://utah.technologypublisher.com/technology/1209Invention SummaryState-of-the-art wireless communication antenna systems lose significant signal strength when users move their device through a wide range of typical orientations as they look up or down, incline the head to hold the device against a shoulder, or change positions from lying to standing. Base-station topologies and wireless device transmitters are designed to accommodate for this loss, but are either too dense, resulting in a large amount of inefficiency, or not being dense enough, resulting in lapses of service. Rotationally diverse antennas solve this problem by improving sig...Wed, 18 Feb 2009 14:46:18 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1209http://utah.technologypublisher.com/technology/1208Invention SummaryA method has been developed for constructing an ion selective electrode inside the pore volume of a glass nanopore electrode. The method consists of chemical or electrochemical depositing reference electrode materials, hydrogels, polymers and ion selective components sequentially to yield an ion selective sensor. The device exhibits exceptional stability in comparison to other miniaturized ion selective electrodes because the electrode materials are contained and protected within the pore. The device is simple to construct and has numerous applications in medical, phar...Wed, 18 Feb 2009 14:46:16 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1208http://utah.technologypublisher.com/technology/1207Invention SummaryRecent technological improvements in the area of micro-electromechanical systems (MEMS) has significantly facilitated the development of some flexible polymer based electrode (Polyamide and PDMS) that will not fracture (when grabbed by forceps or when curved) to match the cylindrical shaped nerves and spherical shaped retina. Although these polymers can be made very thin and may conform to match the targeted surface, not enough is known about the long term effects of pressure in the nerve and retina from an implant to be certain that these substrates will meet long term...Wed, 18 Feb 2009 14:45:48 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1207http://utah.technologypublisher.com/technology/1206Invention Summary In many diagnostic applications, sample preparation is a limiting step in terms of time and/or cost. This technology proposes a method for label-free detection of target molecules, but with the sensitivity of standard fluorescence techniques. Market Applications This technology can be readily adapted to any existing real-time fluorescence detection instrument, whether in solution or on surface. It can also be used in point-of-care and other rapid medical/biowarfare diagnostics, especially if the targets of interest are present in sufficient concentrations to be detected with...Wed, 18 Feb 2009 14:45:44 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1206http://utah.technologypublisher.com/technology/1205Invention SummaryThe invention is a compact device that will provide 2-dimensional tactile feedback to the finger pad of a human. This device would employ a small tactile element or block placed against the user's finger pad to convey shifting contact location or skin shear along the surface of the user's finger pad. This motion will be imparted in the directions both along the length of the finger and laterally. The device's package design is meant to be compact and modular such that it could be placed on the finger pad of a thimble interface or embedded as part of other devices such a...Wed, 18 Feb 2009 14:45:39 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1205http://utah.technologypublisher.com/technology/1204Invention SummaryThis invention is to replace metal-oxide-semiconductor field effect transistors (MOSFETs) in mainstream silicon based microelectronics with junction field 0effect transistors (JFETs) because of their lower leakage and better scaling to nanoscale dimensions. The electrical properties, materials, and fabrication processes of theses devices are compatible with silicon MOSFET technology, and the very similar form factor allows these new devices to essentially be drop-in replacements for MOSFETs. These devices also scale down to at least 10 nm gage lengths, which are planned...Wed, 18 Feb 2009 14:45:39 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1204http://utah.technologypublisher.com/technology/1203Invention Summary There is need in research and clinical applications to develop very high density microarrays with millions of sensing zones per standard microscope slide (7.5 cm x 2.5 cm) or other custom formats. One of the limiting factors in fabrication of the high density arrays is the uncertainty of the size distribution of sensing zones, which leads, in turn, to possible cross-talk between adjacent zones. This technology utilizes prefabrication of the shapes in the sensing zones on the substrate with desired geometry by using photolithography on thin film cladding allows to increase den...Wed, 18 Feb 2009 14:45:38 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1203http://utah.technologypublisher.com/technology/1202Invention Summary Asymmetry of gait refers to a change in the parameters between the left and right limbs, including both asymmetrical distributions of weight, as well as unequal time spent on the left and right feet during stance. Gait asymmetry has been shown to increase with walking speed, and it has been postulated that the asymmetry could account for greater instances of joint degeneration in the intact limb of unilateral amputees. This invention is a device which is able to detect the amount of time that an individual spends on their left foot compared to their right, i.e. it is able to ...Wed, 18 Feb 2009 14:45:37 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1202http://utah.technologypublisher.com/technology/1200Invention Summary3D convex and concave shaped array type curved surfaces are generally fabricated by using polymer molds. Although it is an efficient way of fabricating curved surfaces, but these structures are not mechanically robust. They are prone to deformation especially in humid conditions hence long term reliability of these structures is questionable. This invention is a unique method for fabricating silicon based 3D convex or concave shaped array using variable depth dicing. Spherical/curved (convex) surface array are fabricated by dicing the wafer with different depth that fac...Wed, 18 Feb 2009 14:45:36 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1200http://utah.technologypublisher.com/technology/1199Invention SummaryNeural prosthetics have come a long way and have shown good benefits to individuals. For example, the cochlear prosthesis, which bypass damaged hair cells in the auditory system by direct electrical stimulation of the auditory nerve, and deep brain stimulation, which has been useful for some patients in reducing the motor symptoms associated with Parkinson's Disease. Similarly technological innovations have demonstrated that local electrical stimulation of the retinal neural cells in the blind patient can introduce localized visual perception in blind patients. Conventi...Wed, 18 Feb 2009 14:45:35 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1199http://utah.technologypublisher.com/technology/1198Invention SummaryIn many imaging applications, especially in nuclear medicine such as SPECT (single photon emission computed tomography) and PET (positron emission tomography), the images are blurred due to finite detector resolution. This invention is a fast, non-iterative algorithm to de-blur the image that is suffered from non-stationary point response function (PSR). Market ApplicationsThis invention can be used in medical imaging, especially in nuclear medicine (SPECT and PET) and also in non medical applications where image de-blurring is used. Features and Benefits* The state-of...Wed, 18 Feb 2009 14:45:26 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1198http://utah.technologypublisher.com/technology/1197Invention SummaryCalculation of volumetric projection/backprojection is necessary for reconstruction of tomographic data (e.g. PET, SPECT, CT scanners), but this computation can be very time consuming. This fast projector/backprojector greatly reduces the time needed for reconstruction of 3D tomographic data, while at the same time computing a more accurate projection than many existing projectors because it is a true volumetric projector. All modern PET and PET/CT scanners need 3D reconstruction capability, and this new projector enables this capability in clinically acceptable times....Wed, 18 Feb 2009 14:45:25 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1197http://utah.technologypublisher.com/technology/1196Invention SummaryThe invention is an active hand rest for providing haptic guidance and ergonomic support during precision manipulation tasks such as surgery or hand rehabilitation. This device is envisioned for use in combination with a haptic stylus interface such as a SensAble Technologies PHANToM force feedback device. The active handrest could be implemented with a device such as a 6-degree-of-freedom motion platform, such as a Stewart platform. Versions of the device with either the wrist or the entire arm supported are envisioned. Straps may be employed to ensure greater mechanical coup...Wed, 18 Feb 2009 14:45:15 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1196http://utah.technologypublisher.com/technology/1195Invention SummaryROCR is a pendular two-link, serial chain robot that utilizes alternating hand-holds and an actuated tail to propel itself upward in a climbing style based on observation of human climbers and brachiating gibbons. ROCR's bio-inspired oscillating climbing strategy is very efficient, requiring a minimum of input energy in order to climb vertical walls. Market ApplicationsROCR can be used in a variety of ways. The primary practical application of this robot would be for autonomous inspection, maintenance, and surveillance in elevated or hazardous environments. However, this desig...Wed, 18 Feb 2009 14:45:15 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1195http://utah.technologypublisher.com/technology/1181Invention Summary Today an inactive lifestyle is seen in children as well as adults. Lack of physical activity affects early onset diabetes, obesity, heart disease, and other chronic illnesses. These illnesses have a negative effect on an individual's quality-of-life and functional status. However, it is difficult to fix a problem that cannot be measured well. Current motion monitors for measuring physical activity are expensive ($400-500/each) and ill-suited to many forms of physical activity. Motion-monitors have to be fixed in an upright position at the waist. Often for people with larger w...Tue, 17 Feb 2009 13:08:12 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1181http://utah.technologypublisher.com/technology/1180Invention SummaryA series of novel biodegradable polydisulfide amines were designed and synthesized as nonviral gene delivery carriers with enhanced ability to enter cells (transfection efficiency) and reduced cell death (cytotoxicity). These molecules were synthesized using techniques which result in good biodegradability, strong nucleic acid binding affinity, and high solubility in a variety of solvents. Furthermore, the polydisulfide amines/DNA polyplexes have much lower level of cytotoxicity than similar complexes. This property is particularly attractive because cytotoxicity is a ...Tue, 17 Feb 2009 13:08:11 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1180http://utah.technologypublisher.com/technology/1179Invention Summary Neural stimulation plays a key function for a neuroprosthetic implant. The artificial stimulation of living tissue requires transfer of an external electrical signal from an implantable electro-conductive microelectrode to the neural cells; therefore, the interface between electrode and brain fluid is an important part of the stimulating device, and a key factor for the device performance. Conventionally in the Utah Electrode Array (UEA) an electrochemical process is utilized to oxidize the indium with an anodic iridium oxide film (AIROF) in the tips of UEA. This interface no...Tue, 17 Feb 2009 13:08:08 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1179http://utah.technologypublisher.com/technology/1178Invention Summary This is a simple methodology for correction motion in partially acquired images from Magnetic Resonance Imagining (MRI). This technology will allow object registration for partially acquired images as well as total correction for some images where motion occurs during the acquisition. No other correction information, other than the image data itself, is required. There is currently no technique to correct rigid-body motion during acquisition of an image based upon only the measurements of that image. This technique is able to be used retrospectively to improve the quality of ...Tue, 17 Feb 2009 13:08:08 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1178http://utah.technologypublisher.com/technology/1177Invention Summary Issues associated with the chronic implantation of microelectrode arrays include substantial relative motion between the nerve and its surrounding muscles which can lead to displacement of the array, and the possibility of nerve damage resulting from electrodes being unable to move with the nerve. To overcome this, nerve cuff electrodes are used so that they can be sized to fit snugly around a nerve but yet not restrict nerve movement. Conventional nerve cuff electrodes have been developed, but have been known to inflict neural damage after implantation. This invention is a n...Tue, 17 Feb 2009 13:08:08 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1177http://utah.technologypublisher.com/technology/1176Invention Summary Disorders of the nervous system represent one of the nation's largest health care problems, afflicting more than 100 million Americans and costing more than $700 billion annually. Neural disorders also extract an especially profound toll on the human experience and the quality of life. The high-channel count Utah Electrode Array and Slant Array and its variants are becoming premier neuroprosthetic interfaces for restoring sensory, motor, and other functions after nervous system damage or disease. The array is capable of communicating selectively with large numbers of independ...Tue, 17 Feb 2009 13:07:52 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1176http://utah.technologypublisher.com/technology/1175Invention Summary This technology is a novel method of slice selective excitation which utilizes multiple radiofrequency (RF) transmit coils, each driven by a separate independent control channel, which achieves slice selection with markedly decreased specific absorption rate (SAR, a measure of patient heating). Reduced SAR is achieved with no change in slice profile and no significant increase in excitation time. Market Applications The method is applicable to any slice-selective MRI excitation, which includes the majority of MRI examinations currently performed in clinical practice. The meth...Tue, 17 Feb 2009 13:07:51 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1175http://utah.technologypublisher.com/technology/1174Invention Summary Novel technology, including a technique, hardware and software, has been developed to measure the size, shape and dielectric properties of the interior of a cell/particle and/or cell membrane. This device is based on measurements of current and voltage using a ring of electrodes around the outside of the cell/particle. The approach is a form of micro-electric impedance tomography (micro-EIT) and generates spatially and temporally resolved images of the effective conductance and permittivity of the cell membrane (or interior) based on spectral analysis of electrical fringe-fie...Tue, 17 Feb 2009 13:07:50 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1174http://utah.technologypublisher.com/technology/1173Invention SummaryThis invention relates to peptides derived from cone snail venom, including MrVIA and MrVIB. These peptides block specific sodium channel subtypes which mediate pain signals in dorsal root ganglion neurons, indicating they may be useful treatment for neuropathic and inflammatory pain. Market Applications? Chronic neuropathic pain is estimated to affect up to 8% of the world¿s population. ? Currently, no highly effective treatment is available. In 2005, the European and US neuropathic pain markets were worth $2.5 billion combined. ? Analgesic compounds which are currently presc...Tue, 17 Feb 2009 13:07:45 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1173http://utah.technologypublisher.com/technology/1172Invention SummaryThe adenomatous polyposis coli (APC) gene is a tumor suppressor gene which is altered in many colon cancers. Germline mutations of APC are the cause of familial adenomatous polyposis (FAP), an inherited syndrome which leads to the growth of hundreds of colon polyps and a 100% lifetime risk of developing colon cancer. In addition to its importance in familial colon cancer, the APC gene has been found to be mutated or inactivated in 85% of sporadically arising colon cancers, and loss of normal APC function is an important early event in carcinogenesis. The present inventi...Tue, 17 Feb 2009 13:07:38 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1172http://utah.technologypublisher.com/technology/1171Invention Summary This invention describes the design of a unique semi-permeable membrane with integrated stress and/or pressure sensing elements. The combination of micro channels/membrane and piezoresistive pressure sensing elements on the flexible diaphragm allows the diffusion chemical species of a particular size into a cavity where it can be detected using hydrogels or other chemical-mechanical transducers. The device also is able to measure the stress and or pressure exerted on the diaphragm by aforementioned hydrogel. Permeation through the membrane can be controlled by changing the si...Tue, 17 Feb 2009 13:07:37 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1171http://utah.technologypublisher.com/technology/1170Invention Summary Asynchronous chip design has shown substantial power and performance benefits but is in practice difficult to implement due to the protocol and sequential, rather than combinational, nature of its design. This invention overcomes this by implementing desynchronization as a network with data validity, or DV-Desync. This creates a network with choice, unlike the marked graph counterparts. The choice is taken both from the data path and the control network. This results in an implementation that starts as a clocked design, but the implementation is realized with full asynchronou...Tue, 17 Feb 2009 13:07:36 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1170http://utah.technologypublisher.com/technology/1169Reference Number: U-4295 Invention Description: Viruses infect specific cells within host organisms, replicate, destroy the cells, and spread from cell to cell in infectious cycles, causing diseases. These viral properties have inspired synthetic designs of various delivery vehicles, particularly for toxic anticancer agents that exhibit numerous side effects. Drug delivery vehicles often mimic viral aspects including size and surface properties in improve cell entry and residence within the body before being cleared. Here we describe a synthetic nano-sized polymer vehicle exhibiting ...Tue, 17 Feb 2009 13:07:36 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1169http://utah.technologypublisher.com/technology/1166This technology provides novel engineered Saccharomyces cerevisiae (yeast) cell lines which are useful in bioassays for the identification and measurement of steroid hormone bioactivity. The yeast bioassay system relies on steroid-responsive transcription of a reporter gene that encodes an enzyme, such as ?-galactosidase or luciferase, and quantification of the enzyme indicates the amount and the bioactivity of a steroid hormone in a serum sample. This method can be applied for determination of bioactivity of estrogen, androgen, and progesterone/progestins in human serum and other analytes. Ke...Tue, 17 Feb 2009 13:07:31 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1166http://utah.technologypublisher.com/technology/1164Invention Summary Acquiring less data for magnetic resonance imaging (MRI) images would accelerate the rate at which those images could be acquired. However, using basic techniques to reconstruct images from undersampled data results in either low resolution or undesired image artifacts. Our novel idea is to apply a reduced data reconstruction algorithm, known as constrained reconstruction, to dynamic MRI temperature images. The technique generates accurate temperature maps from undersampled data, allowing images to be acquired 3-6 times faster than when using fully sampled data and traditiona...Tue, 17 Feb 2009 13:07:25 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1164http://utah.technologypublisher.com/technology/1163Invention Summary Proper DNA dosage is essential for normal and cellular development and function. Molecular approaches for the detection of chromosomal abnormalities will allow the development of rapid, cost-effective screening strategies. This invention describes a novel, rapid and highly accurate molecular technique for the detection of chromosomal aneuploidy using quantitative PCR and melting curve analysis. This method can be applied for detection of a number of aneuploidies, including trisomy 21 (Down Syndrome), in embryonic or fetal tissue. Keywords: Prenatal Testing, Down¿s Synd...Tue, 17 Feb 2009 13:07:24 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1163http://utah.technologypublisher.com/technology/1162Invention Summary Conventionally bulk etched silicon substrates have to be attached with a piezoresistive diaphragm in a separate assembly step. This novel process does not require individual processing of the substrate and sensing layer- it takes only one process to manufacture the product. This reduces the overall production costs and simplifies the processing of the sensors. The process also allows for customization of the product by permitting holes to be placed with a specified size and density depending on the size of the diaphragm and application. Market Applications Immediate applicati...Tue, 17 Feb 2009 13:07:21 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1162http://utah.technologypublisher.com/technology/1161Tue, 17 Feb 2009 13:07:20 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1161http://utah.technologypublisher.com/technology/1160Invention SummaryCurrently optical/laser profilometers do not have the ability to apply pressure or vacuum to individual devices or wafers. While laser interferometers are used to measure the overall deflection of diaphragms in pressure sensors, they only provide point measurements on the diaphragm and are susceptible to large error. This technology provides the ability to accurately test pressure sensitive devices and diaphragms using an optical profilometer on both the wafer scale and on the device level. The apparatus is a pressure testing stage designed to hold semiconductor wafers ...Tue, 17 Feb 2009 13:07:12 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1160http://utah.technologypublisher.com/technology/1159Invention Summary This invention includes alpha-conotoxin peptides isolated from the venom of predatory snails and related synthetic derivatives which antagonize the a9a10 nicotinic acetylcholine receptor, which has been associated with neuropathic pain. These peptides are more specific for this receptor subtype than currently available antagonists and represent a previously unrecognized mechanism for treatment of nerve hypersensitivity and neuropathic pain, including sciatica and diabetic neuropathic pain . . Market Applications ¿ Chronic neuropathic pain is estimated to affect up to 8...Tue, 17 Feb 2009 13:06:51 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1159http://utah.technologypublisher.com/technology/1158Invention Summaryhis invention describes a method for the high throughput qualitative and quantitative analysis of dicarboxylic acids, and in particular methylmalonic acid (MMA), which exploits the high specificity of tandem mass spectrometry and selective ionization of dicarboxylic acids. Vitamin B12 (cobalamin) plays an important role in formation of red blood cells and in the maintenance of the central nervous system. Its deficiency can lead to a wide spectrum of hematologic and neuropsychiatric disorders that can be reversed if the condition is diagnosed early and promptly treated. ...Tue, 17 Feb 2009 13:06:33 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1158http://utah.technologypublisher.com/technology/1157Invention SummaryHepcidin is a liver-produced peptide hormone which controls iron absorption by regulating the amount of the cell surface iron transporter ferroportin, which exports iron from cells to blood. Altered hepcidin levels are associated with disorders of iron metabolism and absorption, and disease-associated anemia. Hepcidin also plays an important role in regulation of innate immunity and inflammation. Therapeutic modulation of hepcidin levels could also provide a new approach for the treatment of iron-dependent disorders. Previously, the detection and quantification of hepc...Tue, 17 Feb 2009 13:06:25 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1157http://utah.technologypublisher.com/technology/1156Invention Summary Intermittent electrical faults can be very difficult and frustrating to locate. For some systems they also create safety hazards. These faults are often created by water bridging damaged insulation, vibration of wires against metal structures or other nearby wires, or loose connections. These small problems are very difficult to locate on the ground if the intermittent fault is no longer active. Testing the wires while they are active and in use provides improved fault detection and location. The invention described here improves on existing fault location methods by pro...Fri, 13 Feb 2009 14:42:33 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1156http://utah.technologypublisher.com/technology/1155Invention SummaryThis invention overcomes current limitations of MRI gradient systems, where gradient strength and switching time are limited by the risk of causing stimulation (and pain) in peripheral nerves. In this invention, a gradient insert is used in a manner to increase spatial and temporal resolution while not increasing (and even possibly decreasing) the risk for nerve stimulation. Although the invention allows the use of a gradient insert, it does not lose any advantages of the original system gradients. Because a different device (gradient system) would be developed for each...Fri, 13 Feb 2009 14:42:32 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1155http://utah.technologypublisher.com/technology/1154Invention SummaryNon-viral gene delivery carriers are regarded as alternatives to viral gene delivery carriers. However they have some disadvantages such as relatively low transfection efficiency and some cytotoxicity. This technology is a novel arginine-conjugating bioreducible poly(amido amine) polymer. This polymer is an efficient gene delivery carrier because arginine-conjugation to polymers has been reported to increase their transfection efficiency greatly. In fact, this polymer showed much higher transfection efficiency than unmodified bioreducible poly(amido amine) backbone polymer and...Fri, 13 Feb 2009 14:42:32 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1154http://utah.technologypublisher.com/technology/1153Fri, 13 Feb 2009 14:42:32 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1153http://utah.technologypublisher.com/technology/1152Invention Summary Lenses allow solar cells to achieve unique non-linear behavior with regards to electricity generation, if the solar power concentrated onto them is high enough. Also, they work best with vertically incident light provided by a lens. However current methods for solar cell fabrication cannot benefit from a lens, because the required lens would be too large and the mechanical distance required cannot accommodate for a beam guiding according to the sun's position. While micro lenses overcome these difficulties, the use of micro lenses has typically been cost-prohibitive because o...Fri, 13 Feb 2009 14:42:31 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1152http://utah.technologypublisher.com/technology/1149Invention SummaryStereophonic acoustic echo cancellers often suffer from slow convergence and large deviation of echo canceller tap weights from their true values (misalignment). Both of these happen because of significant correlations among signals in the acoustic paths. Non-linearity effects are usually introduced to reduce such correlations and thereby improve the convergence rate and reduce misalignment. However, non-linearity introduces undesirable effect on the speech signals. This invention introduces a novel method that reduces the correlations without introducing any non-linear...Fri, 13 Feb 2009 14:42:15 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1149http://utah.technologypublisher.com/technology/1148Invention Summary Disorders of the nervous system represent one of the nation's largest health care problems, afflicting more that 100 million Americans and costing more that $700 billion annually. Neural disorders also extract an especially profound toll on the human experience and the quality of life. The high-channel count Utah Electrode Array and Slant Array and its variants are becoming premier neuroprosthetic interfaces for restoring sensory, motor, and other functions after nervous systems damage or disease. The novelty in this technology is that it provides a design improvement that le...Fri, 13 Feb 2009 14:42:14 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1148http://utah.technologypublisher.com/technology/1147Reference Number: U-3738 Invention Description: Metals and metal species are commonly used as catalytic agents in several processes that are of significant commercial interest. Using mixed-metal catalysts can have practical advantages such as higher activities, improved yields etc. The improved catalytic activity is the result of the combined synergistic effects of each of the constituent co-catalysts. Current methods produce randomly distributed metals or metal oxides. As a result, they can suffer from non-selective deposition across the support surface and may not aide in achievin...Fri, 13 Feb 2009 14:42:13 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1147http://utah.technologypublisher.com/technology/1146Reference Number: U-3872 Invention Description: As a patient undergoes chemotherapy two major complications arise: sever side effects of the toxic drugs and resistance of cancerous cells to the drug action. Among these complications the effectiveness of the injected drug is dependent on the tumor¿s vascularization and drug sensitivity. The proposed invention helps overcome these complications through the use of a novel targetable drug delivery system to treat drug sensitive and resistive tumors. The invention uses microbubbles loaded with chemotherapy agents which accumulate around ...Fri, 13 Feb 2009 14:42:10 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1146http://utah.technologypublisher.com/technology/1144Fri, 13 Feb 2009 14:42:03 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1144http://utah.technologypublisher.com/technology/1143 United States Patent Application: 0090256116 Reference Number: U-4357   Invention Description: A major challenge in the implementation of nanomaterials in devices and detection systems is the ability to assemble nanoparticles in a well-controlled manner. Different methods have been developed to control the interaction to achieve a variety of nanoparticle assemblies such as dimer, trimer or tetramers. This technology is a simple versatile solid phase synthesis of gold nanoparticle dimers using an asymmetric functionalizat...]]>Fri, 13 Feb 2009 14:42:02 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1143http://utah.technologypublisher.com/technology/1142Invention SummaryThis device is a compact modular device for providing tactile making and breaking contact sensation to a person's finger pad, as well as providing impact sensation through use of a non-contact distance sensor. It is thimble-based and could be used in combination with a commercial haptic force feedback device. Market ApplicationsThis device would primarily be used to provide tactile contact and/or impact sensation when used in combination with a commercially available 3-D force feedback device. The device can replace the existing thimble interfaces on current commercially avail...Fri, 13 Feb 2009 14:42:01 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1142http://utah.technologypublisher.com/technology/1141Invention Summary Compositions and phase assemblages within the Ta-C system have been developed that result in a composite with mechanical properties (strength and fracture toughness) significantly superior to what has been reported in literature pertaining to tantalum carbide. The measured properties, strength of 675 MPa and fracture toughness of 12.5 MPavm, are exceptionally high for a ceramic and carbide in particular. Market Applications The new material is desirable for such applications as boost rocket motor nozzles that require high thermal-shock resistance. In the commercial sector...Fri, 13 Feb 2009 14:42:01 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1141http://utah.technologypublisher.com/technology/1140Fri, 13 Feb 2009 14:42:01 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1140http://utah.technologypublisher.com/technology/1139Invention Summary Transmission lines can be added to any integrated circuit design to significantly increase the throughput and decrease the power consumption of intermediate and global wires. The designer does not need knowledge of electromagnetics to implement this model. This invention is intended for any type of digital or mixed signal integrated circuit in advanced (100nm or less) semiconductor processes. Initial applications include clock distribution networks and high speed data buses. Both of these applications would benefit from the low-power, low-latency, and high-throughput sign...Fri, 13 Feb 2009 14:42:00 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1139http://utah.technologypublisher.com/technology/1137Fri, 13 Feb 2009 14:41:39 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1137http://utah.technologypublisher.com/technology/1136Fri, 13 Feb 2009 14:41:38 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1136http://utah.technologypublisher.com/technology/1135Fri, 13 Feb 2009 14:41:38 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1135http://utah.technologypublisher.com/technology/1134Fri, 13 Feb 2009 14:41:31 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1134http://utah.technologypublisher.com/technology/1133Fri, 13 Feb 2009 14:41:23 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1133http://utah.technologypublisher.com/technology/1131Invention SummarySporadic colon cancers account for % of all cases of colon cancer, and 85-90% of sporadic tumors are microsatellite stable (MSS). Oncogenic mutations in BRAF are present in a significant number of sporadic colon cancers. This work shows that determination of BRAF mutational status, in particular testing for the BRAFV600E mutation, can identify MSS cancers with a poorer prognosis, allowing identification of patients which are most likely to need aggressive treatment and monitoring. The investigator found that the V600E BRAF mutation, present in approximately 5% of MSS co...Thu, 12 Feb 2009 15:43:44 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1131http://utah.technologypublisher.com/technology/1129Invention Summary Colorectal cancer patients primarily undergo surgery for treatment followed by chemotherapy. The surgical procedure leads to development of a scar in the region of the body lower to the pelvic diaphragm and between the legs, known as perineal scar. During the radiation treatment, this perineal scar resulting from removal of rectum and anus, must also be included. The present invention relates to a novel device for pushing the scar towards the anterior section and properly positioning it during radiation treatment of the rectal area of the patient. The device effectively reduc...Thu, 12 Feb 2009 15:43:31 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1129http://utah.technologypublisher.com/technology/1128Marine natural products have gained increasing importance as a source of potential anticancer agents in the last few decades. Drs. C Ireland and L Barrows are exploring the possibilities to identify novel medicinal compounds having anti-cancer activity. They have identified makaluvamines, a series of cytotoxic marine metabolites, derived from sponges which act as DNA topoisomerase-II inhibitors and sensitized tumor cells, both in cellular based models and mouse tumor model. Naamidine A, also isolated from a marine sponge inhibits the epidermal growth factor (EGF) receptor and its signaling mol...Thu, 12 Feb 2009 15:43:30 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1128http://utah.technologypublisher.com/technology/1127Invention Summary The present invention provides a novel primer design for real-time quantitative allele-specific PCR (AS-PCR), which results in improved sensitivity, specificity and reproducibility of detection. This method provides greatly improved sensitivity and sensitivity for quantitation of low-level polymorphisms and alleles, and can reliably and reproducibly measure low-level alleles at frequencies of 0.1% Keywords: Quantitative PCR, Allele Specificity, Low Frequency Alleles Market Applications The use of this primer design in quantitative kinetic PCR technique has very broad applica...Thu, 12 Feb 2009 15:43:28 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1127http://utah.technologypublisher.com/technology/1125Invention Summary Bortezomib is a targeted cancer drug which acts by blocking proteasomes, clusters of proteins necessary for tumor cell growth. It induces mitochondrial damage in cancer cells. Dr.Ray Lee and co-researchers have identified PKC-d as the downstream effector molecule which mediates the mitochondrial damage and apoptosis in these cancer cells. This invention has shown that identification of molecular targets in the apoptotic pathway which have ability to directly induce cell death and minimize the development of drug resistance, holds great promise to overcome resistance to conven...Thu, 12 Feb 2009 15:43:24 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1125http://utah.technologypublisher.com/technology/1124Invention SummaryPeptide cyclization is a common strategy to engineer better polypeptide-based therapeutics, or other industrial proteins/peptides. Cyclization and crosslinking are achieved in nature using disulfide bridges. This invention consists of methods to create noncovalent crosslinks in peptides in a manner which simplifies chemical synthesis and guides polypeptide folding while simultaneously creating labeled compounds that can be traced in live animals using imaging techniques. Market ApplicationsCyclization methods are time-consuming and difficult to achieve with high yields...Thu, 12 Feb 2009 15:43:24 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1124http://utah.technologypublisher.com/technology/1123Thu, 12 Feb 2009 15:43:23 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1123http://utah.technologypublisher.com/technology/1122Invention Summary Several new diseases involving heavy metal poisoning and radionuclide exposure have been introduced to mankind due to the emergence of new technologies. In addition, the potential for exposure is expected to increase with the continuing industrialization of society. The administration of chelation agents represents the only therapeutic approach, other than symptomatic treatment, for the amelioration of metal and nuclide toxicity. Ethylenetriamine pentaacetic acid (EDTA) and diethylenetriamine pentaacetic acid (DTPA) currently are the only compounds approved for treating su...Thu, 12 Feb 2009 15:43:23 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1122http://utah.technologypublisher.com/technology/1121This invention comprises a pair of gene reporter systems that allow quantification of translational recoding, reinitiation and internal initiation of eukaryotes and prokaryotes by cloning corresponding sequences between two independent light-emitting reporters. The invention is configured for measuring expression of two different luciferases. The system also contains a polylinker for insertion of selected genes to be tested. Recoding is determined by monitoring luminescence of one luciferase (firefly) to the luminescence of the other luciferase (renilla; i.e., sea pansy). Market Applic...Thu, 12 Feb 2009 15:43:16 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1121http://utah.technologypublisher.com/technology/1120This invention describes the identification of an activating mutation in the c-kit tyrosine kinase in a subset of melanomas. Detection of this mutation could indicate that treatment with Imatinib (Gleevec), a targeted therapy which is extremely effective in tumors carrying an activated c-kit mutations, could be beneficial to this subset of patients with malignant melanoma. Keywords: Melanoma, C-kit, Personalized Medicine, Targeted Therapy, Cancer Profiling This invention describes the identification of an activating mutation in the c-kit tyrosine kinase in a subset of melanomas. Detection of t...Thu, 12 Feb 2009 15:43:15 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1120http://utah.technologypublisher.com/technology/1119Invention Summary Ribozymes are RNA molecules that can catalytically cleave nucleic acids, thereby suppressing expression of unwanted gene products such as disease causing proteins. This technology includes various configurations of the hammerhead-class of ribozymes that contain circular, hairpin, circular-hairpin, lariat, and hairpin-lariat ribozyme domain structures. They are catalytically active and provide advantages not present in the wild-type hammerhead configurations. Their production can be accomplished through a variety of techniques, including enzymatic and chemical as well as by...Thu, 12 Feb 2009 15:43:11 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1119http://utah.technologypublisher.com/technology/1118Chronic lymphocytic leukemia (CLL), is the most prevalent form of adult leukemia. A significant limitation to the existing staging system for CLL is the lack of predictability of the rate of disease progression, and poor identification of patients who may benefit from early treatment. This work shows that the global DNA methylation index is a prognostic marker for CLL. Higher levels of DNA methylation are a predictor of more rapid CLL progression, and indicate that the patient is likely to require systemic therapy. Early clinical studies show that DNA methylation levels are predictive o...Thu, 12 Feb 2009 15:43:10 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1118http://utah.technologypublisher.com/technology/1117Invention Summary Antisense technology provides a platform for drug discovery as well as clinical therapeutic applications. Antisense agents (such as DNA, RNA, and ribozymes) bind to complementary regions on host nucleotides and thereby silence the expression of target genes. Given that target genes and their RNA transcripts can be comprised of thousands of nucleotide bases, and given that not all those nucleotides are equally accessible to antisense inhibition, it remains a challenge to design optimal molecules that interact with those target sequences. This technology discloses simple ste...Thu, 12 Feb 2009 15:43:08 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1117http://utah.technologypublisher.com/technology/1116Invention SummaryAdvances in the field of human genome mapping and accumulation of data from mutation screening programs emphasize the need to develop adequate and cost-effective methods for direct molecular haplotyping. Specific haplotypes are associated with an individual¿s disease risk, prognosis, response to therapy, and potential for adverse drug reactions. In the case of infectious disease, specific haplotypes are associated with increased pathogenicity and response to anti-infective therapies. The present inventions are novel and cost-effective methods for discriminating haplotyp...Thu, 12 Feb 2009 15:43:00 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1116http://utah.technologypublisher.com/technology/1115Invention SummaryVery sensitive assays for assaying concentration and profile of steroid biomarkers in small volumes of ovarian follicular fluid have allowed identification of specific steroid profiles which are useful for diagnosis of specific endocrine disorders, and assessing ovarian function. Steroid profiles can allow definitive diagnosis of a variety of endocrine disorders affecting ovarian function and fertility, and will be useful for determining which modes of treatment might be effective. For example, the inventors have identified a specific steroid profiles which is diagnostic for P...Thu, 12 Feb 2009 15:43:00 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1115http://utah.technologypublisher.com/technology/1114Invention SummaryExcessive iron stored in the body is a powerful catalyst for the generation of highly toxic free radicals that can damage all molecular classes found in vivo. The progression of many diseases such as atherosclerosis, cancer, diabetes, and neurogeneration disorders can be arrested by depleting the excessive iron. The invention uses nanoparticle-conjugated chelators that are delivered to diseased organs to sequester or deplete iron. The conjugated nanoparticles can be biodegradable or non-biodegradable depending on the targeted organ. The targeting capabilities of the sy...Thu, 12 Feb 2009 15:42:58 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1114http://utah.technologypublisher.com/technology/1113Invention Summary The present invention provides a method that allows direct sequence analysis of disease genes, in a rapid, accurate, and economical fashion. This method, single condition amplification/internal primer (SCAIP) sequencing, relies on amplification of a large number of exons at a single set of PCR temperatures. Sequencing specificity is achieved by uniform use of a second, nested internal set of sequencing primers. The benefits of this technique are especially apparent in analysis of sequence of large multi-exon genes, including the dystrophin gene ¿ the largest human gene yet kn...Thu, 12 Feb 2009 15:42:31 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1113http://utah.technologypublisher.com/technology/1112Invention SummaryCancer is the second largest cause of death in developed countries, accounting for nearly one in five of all deaths. Polymorphisms of glutathione S-transferase (GST) enzymes have been correlated with altered risk of several cancers, as well as altered response and toxicity from cancer chemotherapy. GST¿s are a family of detoxifying enzymes which inactivate both environmental pollutants and many medications, such as chemotherapeutic agents. Dr. Keller and colleagues have developed a low cost, highly reproducible and specific polymerase chain reaction (PCR) based high-throughput...Thu, 12 Feb 2009 15:42:19 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1112http://utah.technologypublisher.com/technology/1111Thu, 12 Feb 2009 15:42:16 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1111http://utah.technologypublisher.com/technology/1109Invention SummaryThis invention pertains to conantokins, a subset of peptides isolated from cone snail venom. Conantokins are selective NMDA receptor antagonists that hold promise as antiseizure and analgesic therapies with fewer side effects than currently available treatments. Market Applications¿ Epilepsy, characterized by chronic recurrent seizure activity, affects 1 to 3% of the population in the United States. ¿ Currently available therapies antagonize the NMDA receptor, which is expressed as various receptor subtypes. ¿ Conantokin peptides differ from available pharmaceuticals in that t...Thu, 12 Feb 2009 15:42:09 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1109http://utah.technologypublisher.com/technology/1106Invention SummaryThis novel and improved deconvolution method allows high-throughput, quantitative analysis of isobars from unresolved chromatographic peaks, and accurate quantification of isomers or isobars in a complex mixture. Tandem mass spectrometry is attractive for many applications due to its high selectivity, wide dynamic range, and high throughput capabilities. Analysis of isobars and isomers by tandem mass spectrometry is complicated by the similarity between their mass spectra and often requires extensive chromatographic separation in order to eliminate mutual interference, and man...Thu, 12 Feb 2009 15:42:06 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1106http://utah.technologypublisher.com/technology/1103Thu, 12 Feb 2009 15:42:05 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1103http://utah.technologypublisher.com/technology/1091Invention Summary Due to the rising cost of health care, hospitals have been driven to reduce the amount of diagnostic tests being performed, compromising patient treatment. In addition, central chemistry labs are often off-site from the hospital, so when diagnostic test are performed there is often a time delay of anywhere from 4 to 72 hours to get results, again compromising patient treatment. Consequently there is a need for rapid, accurate, small scale sample analysis at the point-of-care (POC). Centrifuge based microfluidic platforms (Lab-on-a-disc) have been commercially used for high...Tue, 03 Feb 2009 14:09:44 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1091http://utah.technologypublisher.com/technology/1083Invention SummaryPolymerase chain reaction has traditionally been used for in vitro modification and amplification of linear DNA. On the other hand, circular closed loop DNA is often the form replicated in host cells. In order to modify host cell DNA constructs, the traditional method has been to work with linearized DNA that must then be cloned back into a circular form before its reintroduction into the host cell. Ligation-during-amplification (LDA) represents a novel approach for the in vitro amplification of closed circular DNA, thereby eliminating the usual required cloning steps ...Mon, 02 Feb 2009 11:40:01 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/1083