http://utah.technologypublisher.comBe the first to know about the latest inventions and technologies available from University of Utahen-USWed, 10 Mar 2010 12:17:42 GMTMon, 08 Feb 2010 10:11:03 GMThttp://blogs.law.harvard.edu/tech/rssdenise@tco.utah.eduCopyright 2010, University of Utahhttp://utah.technologypublisher.com/technology/4547Mon, 08 Feb 2010 10:11:03 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4547http://utah.technologypublisher.com/technology/4546Fri, 05 Feb 2010 12:59:57 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4546http://utah.technologypublisher.com/technology/4364Fri, 18 Dec 2009 14:19:00 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4364http://utah.technologypublisher.com/technology/4319Mon, 14 Dec 2009 17:35:45 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4319http://utah.technologypublisher.com/technology/4318Mon, 14 Dec 2009 17:35:44 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4318http://utah.technologypublisher.com/technology/4317Mon, 14 Dec 2009 17:35:44 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4317http://utah.technologypublisher.com/technology/4316Invention SummaryThe technology in this invention is a minimally invasive procedure for image-guided cancer treatment using contrast-enhanced MRI with photodynamic therapy. The technology includes the administration of MRI contrast-agent-labeled polymer-photosensitizer conjugates, detection of cancer tissues with contrast enhanced MRI and illumination of those tissues with a laser of a certain wavelength. This specific irradiation will activate the photosensitizer accumulated in the tumor or cancer tissue, resulting in cancer cell death. This is an effective treatment to cancer tissues ...Mon, 14 Dec 2009 17:35:43 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4316http://utah.technologypublisher.com/technology/4315Invention Summary Recent advances in technology have led to methods for generating large sets of genomic and proteomic samples. This has created a need for tools that facilitate rapid screening and analysis of these large sets of samples. Immobilization of proteins and nucleic acids on a solid phase is a useful way to perform separation of biomolecules, screen for enzymatic activity, or interrogate for binding events. However, immobilization of macromolecules on a membrane surface with maximum retention of their activity and structural integrity still presents a challenge. Direct covalent a...Mon, 14 Dec 2009 17:35:43 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4315http://utah.technologypublisher.com/technology/4314Invention SummaryAcute Renal Failure (ARF), in the context of multi-organ failure and in high risk patients, remains a common, and often fatal (~50% mortality), complication. Preventative measures are only poorly effective, and dialysis therapy is expensive and time consuming. ARF is characterized by cell injury and death by necrosis and apoptosis in the tubular epithelium. Consequently, recovery from ARF depends on the reestablishment of cells in the damaged area via processes that require surviving cells to both proliferate and migrate into the sites of injury. While growth factors su...Mon, 14 Dec 2009 17:35:42 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4314http://utah.technologypublisher.com/technology/4313Invention Summary Market Applications Features and Benefits IP Status Related Research Mon, 14 Dec 2009 17:35:42 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4313http://utah.technologypublisher.com/technology/4312Mon, 14 Dec 2009 17:35:42 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4312http://utah.technologypublisher.com/technology/4311Mon, 14 Dec 2009 17:35:41 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4311http://utah.technologypublisher.com/technology/4310Mon, 14 Dec 2009 17:35:41 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4310http://utah.technologypublisher.com/technology/4309Invention SummaryIncreasing the concentration of cells and microorganisms by filtration for solid phase imaging and counting is a rapid, sensitive tool. In addition, filtration is used for purification of genomic DNA from biological samples, which is a requisite initial step in the conducting many molecular diagnostic assays. Fluorescent analysis of these small particles directly on the filtration membrane without a transfer step would increase efficiency and reduce cost. However, this is typically limited by membrane autofluorescence. The aluminum oxide-based membrane (AOM), Anopore¿ ...Mon, 14 Dec 2009 17:35:40 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4309http://utah.technologypublisher.com/technology/4308Invention SummaryIn healthy individuals, bone resorption and formation are well balanced, with the bone mass maintained in a steady state. Disturbance of such balance may lead to a number of bone diseases such as osteoporosis, Paget¿s disease, osteoporosis and bone cancer. With the worldwide prevalence of osteoporosis alone estimated at approximately 96 million people in 2004, there is increasing need for effective therapeutics to delay bone disease progression, reverse disease effects, and improve the quality of life for patients. However, most current therapeutics for these diseases a...Mon, 14 Dec 2009 17:35:40 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4308http://utah.technologypublisher.com/technology/4307Invention Summary Cancer is the second leading cause of death by disease in the U.S. It is essential to develop anticancer agents that demonstrate good efficacy without causing systemic toxicity. The cytotoxicity of anticancer agents can be increased by targeting them specifically to the tumor cells. It can be further augmented by directing the anticancer agent to specific subcellular compartments where the drug exerts its action. Dr. Kopecek and colleagues have created a system where drugs are first passively targeted to tumor cells based on conjugation with polymers through a degradable l...Mon, 14 Dec 2009 17:35:39 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4307http://utah.technologypublisher.com/technology/4306Invention SummaryMarket ApplicationsFeatures and BenefitsIP StatusRelated ResearchMon, 14 Dec 2009 17:35:39 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4306http://utah.technologypublisher.com/technology/4305Invention SummaryFebrile seizures are the most common seizure disorder of infancy with a prevalence of 2-5% in European and North American infants. The impact of seizures brought on by elevated body temperature is considerable because individuals who experience them have a 2-7% incidence of developing afebrile seizures and epilepsy later in life. This technology implicates mutations in the sodium channel gene scn9a (nav1.7) in familial and sporadic cases of febrile convulsions and its associated severe complications such as idiopathic generalized epilepsy and intractable epilepsy. It is...Mon, 14 Dec 2009 17:35:39 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4305http://utah.technologypublisher.com/technology/4304Invention Summary There are more than 750,000 tissue and body-part transplants conducted annually, according to the American Association of Tissue Banks. There are many applications that utilize skin grafting: reconstruction after surgery; tissue replacement in burn victims and patients with epidermolysis bullosa (EB); treatment of chronic ulcers; and hair restoration to areas of alopecia. Fresh skin can only be stored for 7 days before cryopreservation is required. As such, most skin transplanted in the U.S. is suboptimal frozen tissue. Availability of higher quality viable tissue would res...Mon, 14 Dec 2009 17:35:38 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4304http://utah.technologypublisher.com/technology/4303Invention Summary The technology in this invention is a water-soluble polymeric drug delivery system for the improved treatment of rheumatoid arthritis and other inflammatory diseases. The delivery system consists of a water-soluble polymer backbone, targeting moieties, and antirheumatic drugs. The polymeric background and the targeting moieties would direct the delivery system specifically to the disease lesions. The uniquely designed linkages that connect the drug to the polymer backbone will be cleaved specifically at the lesions to release the drug. Due to the strong tissue specificity...Mon, 14 Dec 2009 17:35:38 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4303http://utah.technologypublisher.com/technology/4302Invention SummaryPresent-day drug discovery frequently involves screening hundreds of thousands of compounds for biological activity against a target molecule. Compound screening is typically preformed using cell-based systems because they promise accurate, whole-cell data representative of the physiological condition. However, compounds that pass this initial screening often fail in future toxicological testing. Pharmaceutical companies want the closest possible model to the human organism while still retaining the ability to look at several thousand samples quickly and efficiently. Fl...Mon, 14 Dec 2009 17:35:37 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4302http://utah.technologypublisher.com/technology/4301Invention Summary Market Applications Features and Benefits IP Status Related Research Mon, 14 Dec 2009 17:35:37 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4301http://utah.technologypublisher.com/technology/4300Invention Summary The present invention provides a novel method to use alkylaryl polyether alcohol polymers as antioxidants to block oxidant reactions and prevent tissue injury and disease that are related to overproduction of partially reduced dioxygen (O2) species, such as chronic pulmonary inflammation, myocardial infarction and stroke, adult respiratory distress syndrome, and oxygen toxicity of the lung. This invention shows that by inhibiting the activation of nuclear transcription factor NF-?B, alkylaryl polyether alcohol polymers can inhibit the cellular production of pro-inflammatory c...Mon, 14 Dec 2009 17:35:37 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4300http://utah.technologypublisher.com/technology/4299Invention Summary The present invention provides a method for suppressing malignant melanoma proliferation by inhibiting NAD(P)H oxidase enzymes from generating reactive oxygen species (ROS). Malignant melanoma cells spontaneously generate ROS that promote constitutive activation of the transcription factor nuclear factor-kB (NF-kB), which in turn activates cell proliferation. This invention showed that melanoma proliferation was reduced by inhibiting the function of NAD(P)H oxidase and production of its ROS signaling products. It also showed that the generation of intracellular ROS in mela...Mon, 14 Dec 2009 17:35:36 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4299http://utah.technologypublisher.com/technology/4298Invention SummaryThough oxidative stress is widely implicated in pathogenic states including aging and heart failure, the role of reductive stress, which is defined as the abnormal increase of reducing equivalents (e.g., glutathione, NADPH), remains controversial. The present invention provides genetic, molecular, and biochemical evidence for showing the role of reductive stress in mammals, and proposes novel and, potentially personalized, therapeutic strategies to use anti-reductants for the treatment of human diseases such as heart failure, diabetes mellitus, and degenerative diseases. Anti-...Mon, 14 Dec 2009 17:35:36 GMTdenise@tco.utah.eduhttp://utah.technologypublisher.com/technology/4298