Search Results - Biomarkers

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Novel Biomarkers for Chronic Fatigue and Fibromyalgia

Summary: Changes in gene expression levels of key molecular receptors associated with fatigue and pain are detected in blood following moderate exercise, together with changes in cytokine levels. This provides a simple, non-invasive test for accurate diagnosis of fatigue and pain related disorders, for tracking patient response to therapy, and...

Published: 11/2/2017 | Inventor(s): Alan Light, Kathleen Light, Ronald Hughen

Keywords(s): Non-Cancer Disease Diagnostics, Omics

Category(s): Diagnostics, Biomarkers

Genetic Alterations in Glioblastoma

Invention SummaryA global pattern/signature of DNA copy number alterations has been shown to have prognostic utility for gliomas and glioblastoma multiforme, types of brain cancers. Specific patterns are associated with survival time and response to chemotherapy. Value PropositionCurrently, the best predictor of prognosis for gliomas is the patient’s...

Published: 8/14/2019 | Inventor(s): Orly Alter

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Category(s): Diagnostics, Biomarkers

Improved Mass Spectrometry Assay for Measurement of Thyroglobulin

Invention SummaryMeasurement of thyroglobulin is used to monitor patients after treatment for differentiated thyroid carcinoma. After total thyroidectomy and radioactive ablation, serum concentrations of thyroglobulin should decrease to very low levels. A rise of serum concentration of thyroglobulin is indicative of cancer recurrence. In about 30%...

Published: 3/21/2019 | Inventor(s): Mark Kushnir, Alan Rockwood, A. Wayne Meikle

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Category(s): Diagnostics, Biomarkers

A Sensor to Detect Volatile Organic Biomarkers

Invention Summary Diseases such as lung cancer and diabetes cause changes in body chemistry that result in the release of volatile organic biomarkers distinct from those of healthy patients. University of Utah Inventors developed a technology for detecting lung cancer biomarkers. Specifically, a novel colorimetric assay creates a sensitive and selective...

Published: 12/29/2016 | Inventor(s): Prashant Kumar Sarswat, Michael Free

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Category(s): Biomarkers, Chemicals, Medical Devices

Molecular Test to Determine Cancer Risk of Serrated Polyps

Invention SummaryA new biomarker-based diagnostic test to assess the cancer risk of Sessile Serrated Adenomas and Polyps (SSA/P) has been developed and is available for licensing. Previously considered benign, new evidence suggests that SSA/Ps may account for up to 35% of the 136,000 cases of colon cancer diagnosed each year in the U.S. Features...

Published: 5/2/2019 | Inventor(s): Curt Hagedorn, Don Delker, Randall Burt

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Category(s): Diagnostics, Biomarkers

Biomarkers for Individualized Breast Cancer Risk Assessment

Invention SummaryAlthough family history can increase breast-cancer risk, women from high-risk families face substantial uncertainty regarding their personal risk. University of Utah investigators have identified gene expression profiles in peripheral blood which can accurately identify those high-risk patients who are most likely to develop breast...

Published: 8/18/2017 | Inventor(s): Andrea Bild, William Johnson, Saundra Buys

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Category(s): Diagnostics, Oncology, Biomarkers

Sensitive LC-MS/MS Assay for 5a-Dihydrotestosterone and Other Analytes

Invention Summary Measurement of testosterone and other androgens has many clinical applications. Measurement of serum androgens is important in adult, geriatric, pediatric endocrinology, and oncology patients. Immunoassays for androgens are often inaccurate due to analytical interferences, and measurement results often overestimate the true concentration,...

Published: 5/2/2019 | Inventor(s): Bingfang Yue, Alan Rockwood, Mark Kushnir, A. Wayne Meikle

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Category(s): Diagnostics, Biomarkers

Marker for Prognosis and Drug Resistance of Ewing's Sarcoma

Summary: Researchers at the University of Utah are working to develop methods for early detection and improved treatment of Ewing's sarcoma. They have identified glutathione-S-transferase M4 (GSTM4) as a critical target gene in this cancer. GSTM4 contributes to tumorigenesis and drug resistance in Ewing's sarcoma. Patients with higher levels...

Published: 5/2/2019 | Inventor(s): Stephen Lessnick, Wen Luo

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Category(s): Diagnostics, Biomarkers

Biomarker for Improved Diagnosis of Ewing’s Sarcoma

Invention SummaryEwing’s sarcoma is a highly aggressive bone or soft tissue-associated tumor of children and young adults. The tumor frequently progresses undetected until it metastasizes, whereupon the mortality of the disease greatly increases. This technology reveals a new molecular marker, NKX2.2, which has high specificity and sensitivity...

Published: 8/13/2019 | Inventor(s): Stephen Lessnick

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Category(s): Diagnostics, Biomarkers