Search Results - alan+rockwood

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Improved Mass Spectrometry Assay for Measurement of Thyroglobulin

Invention SummaryMeasurement of thyroglobulin is used to monitor patients after treatment for differentiated thyroid carcinoma. After total thyroidectomy and radioactive ablation, serum concentrations of thyroglobulin should decrease to very low levels. A rise of serum concentration of thyroglobulin is indicative of cancer recurrence. In about 30%...

Published: 3/21/2019 | Inventor(s): Mark Kushnir, Alan Rockwood, A. Wayne Meikle

Keywords(s):

Category(s): Diagnostics, Biomarkers

Method for Calibration and Correction of Mass Spectrometry with Reduced Interference from Internal Standards

Invention Summary Isotopically labeled internal standards are widely used in mass spectrometry (MS) analysis, with the assumption that there is no interference or cross-talk between the internal standard and analyte. This can result in nonlinear data, limited dynamic range, and inaccurate assessment of analyte concentration. Two simple equations,...

Published: 3/19/2019 | Inventor(s): Geoffrey Rule, Zlatuse Clark, Bingfang Yue, Alan Rockwood

Keywords(s):

Category(s): Diagnostics, Software

Sensitive LC-MS/MS Assay for 5a-Dihydrotestosterone and Other Analytes

Invention Summary Measurement of testosterone and other androgens has many clinical applications. Measurement of serum androgens is important in adult, geriatric, pediatric endocrinology, and oncology patients. Immunoassays for androgens are often inaccurate due to analytical interferences, and measurement results often overestimate the true concentration,...

Published: 5/2/2019 | Inventor(s): Bingfang Yue, Alan Rockwood, Mark Kushnir, A. Wayne Meikle

Keywords(s):

Category(s): Diagnostics, Biomarkers

Quantitative Analysis of Unresolved Isomers and Isobars by Tandem Mass Spectrometry

Summary: Tandem mass spectrometry is attractive for many applications due to its high selectivity, wide dynamic range, and high throughput capabilities. Analysis of isobars and isomers by tandem mass spectrometry is complicated by the similarity between their mass spectra and often requires extensive chromatographic separation in order to eliminate...

Published: 8/23/2019 | Inventor(s): Mark Kushnir, Alan Rockwood, Gordon Nelson

Keywords(s): Computer Software, Non-Cancer Disease Diagnostics, Research Tools

Category(s): Diagnostics, Assay Platforms