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Highly Potent Bryostatin Analogues Prepared Using a Pyran Annulation Process

Invention Description: Bryostatin 1 has been shown to act synergistically in combination with other chemotherapeutic agents to modulate protein kinase C (PKC) activity, with a potent anti-leukemic effect and action against lung, prostate and non-Hodgkin's lymphoma tumor cells. Despite this promise, no readily renewable supply of bryostatin 1 exists,...

Published: 8/14/2019 | Inventor(s): Gary Keck, Matthew Kraft, Anh Truong, Carina Sanchez, Wei Li, Jonathan Covel, Dennie Welch, Yam Poudel

Keywords(s):

Category(s): Biotechnology, Proteomics