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New Therapeutic Strategy for Inhibition of Angiogenesis and Lymphangiogenesis Using Targeted Morpholinos

Invention Summary The invention presents a new strategy for inhibition of angiogenesis and lymphangiogenesis through manipulation of VEGFR isoform expression. The VEGFR1 and VEGFR2 genes produce both membrane-bound and soluble isoforms, which have differing effects on these processes. The membrane bound isoforms promote angiogenesis, while...

Published: 3/5/2020 | Inventor(s): Bala Ambati, Hironori Uehara

Keywords(s): Gene Therapy, Silencing & Editing, Therapeutics

Category(s): Therapeutics, Therapeutics, Gene Therapy, Silencing & Editing