Search Results - therapeutics

34 Results

Sort By:

HPMA-based active targeted polymer-anticancer drug conjugates

TECHNOLOGY SUMMARYDrug delivery Pioneer, Dr. Jindřich Kopeček has innovated the next generation of Antibody Drug Conjugates (ADC) with high efficacy tumor targeting and minimal off-target toxicity. The innovative approach involves a controlled living polymerization technique which results in a well-defined semitelechelic maleimide functionalized HPMA...

Published: 9/13/2019 | Inventor(s): Jiyuan Yang, Jindrich (henry) Kopecek, Libin Zhang, Yixin Fang

Keywords(s): Biologics, Therapeutics

Category(s): Therapeutics, Biologics

Novel Peptide for Intervention in Metabolic Syndrome and Obesity

TECHNOLOGY SUMMARYA novel peptide corrects a multitude of abnormalities associated with metabolic syndrome, including obesity, hyperglycemia, and insulin resistance, and is highly potent.BENEFITSNovel biologic agent for intervention in metabolic syndrome and obesity. MARKET OPPORTUNITY The global obesity treatment market is expected to reach USD 15.6...

Published: 4/3/2020 | Inventor(s): Tianxin Yang

Keywords(s): Biologics, Therapeutics

Category(s): Therapeutics, Biologics

T Cell Clone-Specific Immune Checkpoint Therapy

TECHNOLOGY SUMMARYThis technology aims to greatly improve the existing and future immune checkpoint therapies for the treatment of cancer. While current methods of immunotherapy are successful at infiltrating tumor cells and attacking them, they can also begin to attack the hosts’ normal tissues that can be harmful to organs. This invention provides...

Published: 7/18/2019 | Inventor(s): Mingnan Chen, Peng Zhao

Keywords(s):

Category(s): Therapeutics, Biologics

Drug Repurposing for Treatment of NGLY1 Deficiency

TECHNOLOGY SUMMARY A class of FDA approved drugs may be repurposed for use in treating NGLY1 deficiency. NGLY1 deficiency is a rare genetic disorder, caused by a lack of the enzyme N-glycanase, characterized by a variety of debilitating and isolating symptoms, including global developmental delay, movement disorders, seizures, ocular abnormalities,...

Published: 6/6/2019 | Inventor(s): Kuberan (kuby) Balagurunathan, Matthew Brendon Might, Yiling Bi

Keywords(s):

Category(s): Therapeutics, Drug Repurposing

Methods to Treat Dry Mouth in Sjögren’s Syndrome

Invention SummarySjögren’s syndrome is an autoimmune disease that affects the entire body. The most common symptoms include dry eyes and dry mouth which causes pain for the patient and can make it difficult to swallow or speak. Sjögren’s syndrome is one of the most dominant autoimmune diseases, with upwards of 4 million American’s...

Published: 5/7/2019 | Inventor(s): Olga Baker, Kihoon Nam, Pedro Lei, Stelios Andreadis

Keywords(s):

Category(s): Therapeutics, Drug Delivery

Nanoparticles to Orally Deliver Injectable Therapeutics

Invention SummaryThe technology makes nanoparticles orally available by utilizing the enterohepatic circulation pathway of bile acids in the epithelium of the distal ileum. The nanoparticles can carry various payloads of genetic materials such as, plasmid DNA (encoding particular proteins), active proteins/peptides (e.g., insulin), and small molecules...

Published: 5/7/2019 | Inventor(s): You Han Bae, Yong-Kyu Lee, Md Nurunnabi

Keywords(s):

Category(s): Therapeutics, Drug Delivery

BH4 (KUVAN) for Treatment of Systemic Sclerosis Vasculopathy

Invention SummarySystemic Sclerosis (SSc) SSc is a multisystem autoimmune disorder with a progressively devastating course. There is increased fibroblast activity resulting in abnormal growth of connective tissue causing vascular damage and fibrosis. Fibrosis occurs in skin, the gastrointestinal (GI) tract and other internal organs ;leading to digital...

Published: 9/13/2019 | Inventor(s): Anthony Donato, Tracy Frech

Keywords(s): Drug Repurposing, Therapeutics

Category(s): Therapeutics, Drug Repurposing

Naonparticle Antibody Conjugate Platform For Targeted Delivery and Tumor Killing

Invention SummaryMonoclonal antibody as a single agent therapy for solid and blood cancers show limited clinical efficacy. High doses are needed which result in undesired adverse immunogenicity and toxicity. Conjugating antibodies to cytotoxic drug show durable clinical response. However ADC designing is complex, with knowledge of linkers, drug and...

Published: 9/13/2019 | Inventor(s): Xinjian Chen, Chengke Luo

Keywords(s): Biologics, Therapeutics

Category(s): Therapeutics, Biologics

Novel Inhibitors of Inflammatory Injury Caused by Neutrophil Extracellular Traps (NETs)

Invention Summary The inventors have developed a novel means of inhibiting NET development and preventing further tissue injury associated with inflammation, both of which will decrease morbidity and mortality. While NET formation is a potent mechanism of killing microbes, there is emerging evidence that NETs mediate vascular and tissue injury in inflammatory...

Published: 9/13/2019 | Inventor(s): Christian Yost, Guy Zimmerman, Andrew Weyrich

Keywords(s): Biologics, Therapeutics

Category(s): Therapeutics, Biologics

Broadly Protective Pandemic and Seasonal Influenza Vaccines

Invention SummaryA novel methodology has been developed with the promise of creating a functional universal seasonal and pandemic influenza vaccine. U-4621 focuses on ablating the hemagglutinin (HA) primary antigenic determinants and replacing them with less commonly occurring amino acids. This alerts the immune system into recognizing the viral threat,...

Published: 5/7/2019 | Inventor(s): Susan Bock

Keywords(s):

Category(s): Therapeutics, Vaccines & Adjuvants

1 2 3 4