Search Results - matthew+brendon+might

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Drug Repurposing for Treatment of NGLY1 Deficiency

TECHNOLOGY SUMMARY A class of FDA approved drugs may be repurposed for use in treating NGLY1 deficiency. NGLY1 deficiency is a rare genetic disorder, caused by a lack of the enzyme N-glycanase, characterized by a variety of debilitating and isolating symptoms, including global developmental delay, movement disorders, seizures, ocular abnormalities,...

Published: 6/6/2019 | Inventor(s): Kuberan (kuby) Balagurunathan, Matthew Brendon Might, Yiling Bi

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Category(s): Therapeutics, Drug Repurposing

Epileptic Seizure Prevention Software

Invention SummaryA novel multimodal suite for epilepsy self-management and the prevention of epileptic seizures is under development. This invention facilitates the use of mobile medical applications and software as therapeutic tools for patients who suffer from epilepsy. The application provides the patient with self-management and prevention exercises...

Published: 4/2/2020 | Inventor(s): Grzegorz Bulaj, Carol Bruggers, Pegah Afra, Matthew Sweney

Keywords(s): Medical Devices, Neurology

Category(s): Neurology, Medical Devices

Molecular Test to Determine Cancer Risk of Serrated Polyps

Invention SummaryA new biomarker-based diagnostic test to assess the cancer risk of Sessile Serrated Adenomas and Polyps (SSA/P) has been developed and is available for licensing. Previously considered benign, new evidence suggests that SSA/Ps may account for up to 35% of the 136,000 cases of colon cancer diagnosed each year in the U.S. Features...

Published: 5/2/2019 | Inventor(s): Curt Hagedorn, Don Delker, Randall Burt

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Category(s): Diagnostics, Biomarkers

Highly Potent Bryostatin Analogues Prepared Using a Pyran Annulation Process

Invention Description: Bryostatin 1 has been shown to act synergistically in combination with other chemotherapeutic agents to modulate protein kinase C (PKC) activity, with a potent anti-leukemic effect and action against lung, prostate and non-Hodgkin's lymphoma tumor cells. Despite this promise, no readily renewable supply of bryostatin 1 exists,...

Published: 8/14/2019 | Inventor(s): Gary Keck, Matthew Kraft, Anh Truong, Carina Sanchez, Wei Li, Jonathan Covel, Dennie Welch, Yam Poudel

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Category(s): Biotechnology, Proteomics

A General Catalyst for the Conversion of Terminal Alkenes to Methyl Ketones

Invention Description: This technology describes an improved, highly selective and efficient method for the palladium-catalyzed Wacker oxidation of diverse substrates. The key component of the new catalytic system is Quinox ligand. This ligand is easily prepared in two steps and structurally unique leading to a highly active and selective catalyst...

Published: 8/14/2019 | Inventor(s): Matthew Sigman, Brian Michel

Keywords(s): Chemicals

Category(s): Research Tools & Reagents, Reagents

Emergency Release Snowboard Binding (ERSB)

Invention Summary: Unlike ski bindings, snowboard bindings have no release mechanism that allows the rider to quickly be separated from the snowboard case of an emergency. As a result, if a snowboarder is caught in an avalanche, the snow flowing over the board typically drags the snowboarder to the bottom of the avalanche. This drastically reduces the...

Published: 8/3/2017 | Inventor(s): Eberhard Bamberg, Michael Allen, Blake Anderson, David Call, Gavin Mehraban, Matthew Sartori, Michael Weidner, Jason Wendel

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