Search Results - reagents

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New Plasmids and Methods for Transgene-free Induced Pluripotent Stem Cells (iPSC)

Invention SummaryNovel tools and methods have been developed to generate Induced Pluripotent Stem Cells (iPS) cells with applications in stem cell research and regenerative medicine. Novel reprogramming factors have been assembled on a single non-integrating plasmid to produce germ-line competent, transgene free iPS cells.Value Propositiono Improved...

Published: 5/7/2019 | Inventor(s): Sen Wu, Yuanyuan Wu, Mario Capecchi

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Category(s): Research Tools & Reagents, Reagents

Nickel-Based Reagents for Detecting DNA and DNA-Protein Contacts **Value Express**

Patent Abstract The invention relates to a compound comprising a labeled nickel complex (FIG. 1) that is used to detect and purify nucleic acid sequences by forming an adduct between a specific nucleic acid base and the labeled nickel complex. The adduct can also be purified through a separation process, such as affinity chromatography Intellectual...

Published: 3/22/2019 | Inventor(s): Steven Rokita, Cynthia Burrows

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Category(s): Research Tools & Reagents, Reagents

Pharmacokinetics of Highly Fluorinated Amino Acids

Patent AbstractDisclosed are compounds having the structure: wherein R1a and R1b are independently H, alkyl, F, or fluoroalkyl; wherein R2a, R2b, R2a′, and R2b′ are independently H, alkyl, F, fluoroalkyl, aryl, or alkenyl; wherein R3 is OH, alkoxyl, NH2, alkylamino, or dialkylamino; wherein R4a and R4b are independently H, alkyl, acyl,...

Published: 3/25/2019 | Inventor(s): Yihua Bruce Yu, Zhong-Xing Jiang

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Category(s): Research Tools & Reagents, Reagents

Covalent Tethers for Isolating Homogeneous Proteins

Invention Summary: Recent advances in technology have led to methods for generating large sets of genomic and proteomic samples. This has created a need for tools that facilitate rapid screening and analysis of these large sets of samples. Immobilization of proteins and nucleic acids on a solid phase is a useful way to perform separation of biomolecules,...

Published: 10/1/2019 | Inventor(s): C. Dale Poulter, Guillermo Roberto Labadie, Cecile Gauchet, Rochelle Frances Hawkins Bohaty

Keywords(s): Reagents, Research Tools & Reagents

Category(s): Research Tools & Reagents, Reagents

Penumbra Nucleic Acid Molecules, Proteins and Methods of Their Detection and Use, Especially for Myeloid (Bone Marrow) Diseases

Invention Description: This invention identifies the human Penumbra gene nucleic acid molecules, proteins encoded by these nucleic acid molecules, antibodies raised against these proteins, and inhibitors of these proteins. The invention also includes methods of using these molecules in the detection of disease, including human myeloid malignancies....

Published: 5/7/2019 | Inventor(s): Schickwann Tsai, Zhong Chen

Keywords(s): Non-Cancer Disease Therapeutics, Research Tools

Category(s): Research Tools & Reagents, Reagents

A General Catalyst for the Conversion of Terminal Alkenes to Methyl Ketones

Invention Description: This technology describes an improved, highly selective and efficient method for the palladium-catalyzed Wacker oxidation of diverse substrates. The key component of the new catalytic system is Quinox ligand. This ligand is easily prepared in two steps and structurally unique leading to a highly active and selective catalyst...

Published: 8/14/2019 | Inventor(s): Matthew Sigman, Brian Michel

Keywords(s): Chemicals

Category(s): Research Tools & Reagents, Reagents