Search Results - mario+capecchi

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New Plasmids and Methods for Transgene-free Induced Pluripotent Stem Cells (iPSC)

Invention SummaryNovel tools and methods have been developed to generate Induced Pluripotent Stem Cells (iPS) cells with applications in stem cell research and regenerative medicine. Novel reprogramming factors have been assembled on a single non-integrating plasmid to produce germ-line competent, transgene free iPS cells.Value Propositiono Improved...

Published: 5/7/2019 | Inventor(s): Sen Wu, Yuanyuan Wu, Mario Capecchi

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Category(s): Research Tools & Reagents, Reagents

A Mouse Model of Synovial Sarcoma

Invention Summary: The present invention provides the first and only genetic mouse model of synovial sarcoma, a highly aggressive, malignant childhood/young adult soft tissue cancer. This mouse model was generated by conditionally expressing the human SYT-SSX2 fusion protein with myoblasts. It faithfully recapitulates human synovial sarcoma in presentation,...

Published: 7/10/2019 | Inventor(s): Malay Haldar, Mario Capecchi

Keywords(s):

Category(s): Research Tools & Reagents, Animal Models