Search Results - research+tools+%26+reagents

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Invention SummaryA new technology with the potential to identify antimicrobials is being developed. Screening for antimicrobials is one of the most significant stages of drug development. This technology takes advantage of the unique bacterial biology/biochemistry, the differences in drug metabolism and the differences in drug import/export in order...

Published: 11/2/2017 | Inventor(s): John Phillips, Harry Dailey

Keywords(s):

Category(s): Research Tools & Reagents, Screening Assays

Colorectal Cancer Patient-derived Xenografts

Invention SummaryA method for creating in vivo patient-derived xenograft (PDX) models for colorectal cancer patients has been developed. These models are being made by inserting a fresh piece of a patient’s tumor into an appropriate anatomical location on immune-deficient mice. This allows for a more personalized and high-fidelity model of individual...

Published: 5/7/2019 | Inventor(s): Alana Welm, David Lum

Keywords(s):

Category(s): Research Tools & Reagents, Screening Assays

Synthesis of Cyclic Peptide and Cyanobactin Libraries

Invention SummaryNovel methods have been developed to create natural peptide libraries. These technologies would produce libraries of cyanobactins and other cyclic peptides using multiple production methods. The first method focuses on cyclic peptide synthesis using amide-linked peptides that are created in vivo. The method would be able to identify...

Published: 8/15/2019 | Inventor(s): Eric Schmidt, Duane Ruffner, Diarey Tianero, Elizabeth Pierce, Baldomero Olivera

Keywords(s):

Category(s): Research Tools & Reagents, Screening Assays

Detecting Base-Pair Mismatches and Modifications in Polynucleotides through Base Flipping

Invention SummaryThis technology proposes a novel way of detecting localized conformational mutations in DNA, also known as single nucleotide polymorphisms (SNPs), through utilizing a protein nanopore alpha hemolysin. Using this technology, base pair mismatches can be identified by measuring local conformational changes in the DNA molecule, from which...

Published: 3/19/2019 | Inventor(s): Henry White, Cynthia Burrows, Robert Johnson, Aaron Fleming

Keywords(s):

Category(s): Research Tools & Reagents

New Plasmids and Methods for Transgene-free Induced Pluripotent Stem Cells (iPSC)

Invention SummaryNovel tools and methods have been developed to generate Induced Pluripotent Stem Cells (iPS) cells with applications in stem cell research and regenerative medicine. Novel reprogramming factors have been assembled on a single non-integrating plasmid to produce germ-line competent, transgene free iPS cells.Value Propositiono Improved...

Published: 5/7/2019 | Inventor(s): Sen Wu, Yuanyuan Wu, Mario Capecchi

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Category(s): Research Tools & Reagents, Reagents

A Device and the Assembly of a Microfluidic In-Vitro Blood Brain Barrier Module

Invention SummaryThis technology combines microfluidic channels, cultured cells, and embedded electrodes in a single module to study the blood brain barrier (BBB) in a robust, highly manipulable, and replicable module. This is the first such in vitro model to combine all three of these features, making it one of the best research tools for studying...

Published: 5/7/2019 | Inventor(s): Hanseup Kim, Ross Booth

Keywords(s):

Category(s): Research Tools & Reagents, Instrumentation

A Novel Ex vivo Model to Study Viral Latency

Invention SummaryAlthough current retroviral therapies can reduce HIV to undetectable levels, latent HIV virus continues to persist in hidden reservoirs within resting memory T cells. These reservoirs are widely recognized as a key obstacle which must be overcome to achieve a cure. Once a patient stops the antiretroviral regimen, the latent virus...

Published: 8/23/2019 | Inventor(s): Vicente Planelles, Alberto Bosque

Keywords(s):

Category(s): Research Tools & Reagents, Screening Assays

Circuit Modification of Electrical Field Flow Fractionation Systems for High Resolution Separations of Sub 100nm Nanoparticles and Macromolecules

Invention SummaryCyclical Electrical Field Flow Fractionation (CyEFFF) is a technique used for the separation of macromolecular, colloidal and nanometer-sized particles. Previously, CyEFFF could not separate particles smaller than 70 nm however by changing the electrical circuitry driving the CyEFFF system, the inventors are able to separate particles...

Published: 8/17/2018 | Inventor(s): Tonguc Onur Tasci, Bruce Gale, William Johnson

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Category(s): Research Tools & Reagents, Microfluidics

Simultaneous Amplification and 3-D Detection of Deoxyribonucleic acid by an Optical Method **Value Express**

Patent Abstract Methods of performing PCR are provided. Methods may include using an optical source to provide heating for thermocyling the PCR reaction. Methods may include using surface plasmon resonance and/or fluorescence resonance enhanced transfer to allow real-time monitoring of a PCR reaction. Methods may include immobilizing a template,...

Published: 5/7/2019 | Inventor(s): D. Keith Roper

Keywords(s):

Category(s): Research Tools & Reagents, Instrumentation

Nickel-Based Reagents for Detecting DNA and DNA-Protein Contacts **Value Express**

Patent Abstract The invention relates to a compound comprising a labeled nickel complex (FIG. 1) that is used to detect and purify nucleic acid sequences by forming an adduct between a specific nucleic acid base and the labeled nickel complex. The adduct can also be purified through a separation process, such as affinity chromatography Intellectual...

Published: 3/22/2019 | Inventor(s): Steven Rokita, Cynthia Burrows

Keywords(s):

Category(s): Research Tools & Reagents, Reagents

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