Search Results - screening+assays

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Invention SummaryA new technology with the potential to identify antimicrobials is being developed. Screening for antimicrobials is one of the most significant stages of drug development. This technology takes advantage of the unique bacterial biology/biochemistry, the differences in drug metabolism and the differences in drug import/export in order...

Published: 11/2/2017 | Inventor(s): John Phillips, Harry Dailey

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Category(s): Research Tools & Reagents, Screening Assays

Colorectal Cancer Patient-derived Xenografts

Invention SummaryA method for creating in vivo patient-derived xenograft (PDX) models for colorectal cancer patients has been developed. These models are being made by inserting a fresh piece of a patient’s tumor into an appropriate anatomical location on immune-deficient mice. This allows for a more personalized and high-fidelity model of individual...

Published: 5/7/2019 | Inventor(s): Alana Welm, David Lum

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Category(s): Research Tools & Reagents, Screening Assays

Synthesis of Cyclic Peptide and Cyanobactin Libraries

Invention SummaryNovel methods have been developed to create natural peptide libraries. These technologies would produce libraries of cyanobactins and other cyclic peptides using multiple production methods. The first method focuses on cyclic peptide synthesis using amide-linked peptides that are created in vivo. The method would be able to identify...

Published: 8/15/2019 | Inventor(s): Eric Schmidt, Duane Ruffner, Diarey Tianero, Elizabeth Pierce, Baldomero Olivera

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Category(s): Research Tools & Reagents, Screening Assays

A Novel Ex vivo Model to Study Viral Latency

Invention SummaryAlthough current retroviral therapies can reduce HIV to undetectable levels, latent HIV virus continues to persist in hidden reservoirs within resting memory T cells. These reservoirs are widely recognized as a key obstacle which must be overcome to achieve a cure. Once a patient stops the antiretroviral regimen, the latent virus...

Published: 8/23/2019 | Inventor(s): Vicente Planelles, Alberto Bosque

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Category(s): Research Tools & Reagents, Screening Assays

Assay for Determining Relative Redox Changes in Living Cells

Brief Description of the TechnologyThe current invention is a peptide construct that has been modified by fluorophores to monitor redox changes in live cells. The extent of fluorescence is dependent on the cellular GSH/GSSG ratio and is measured using a simple fluorescent plate reader. The technology has been validated with known redox active compounds....

Published: 5/7/2019 | Inventor(s): Shayne Squires, Ivor Benjamin

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Category(s): Research Tools & Reagents, Screening Assays

Performance of Organisms in Phenotrons (POP) Assays

**VALUE EXPRESS** Invention Description: We are exposed daily to chemicals, pharmaceuticals, vaccines, therapeutic agents, pathogens, electromagnetic radiation, excess or deficiencies of nutrients, food additives, food supplements and numerous other exogenous insults that may have unforeseen and adverse effects on our health. Consequently, there is...

Published: 9/6/2018 | Inventor(s): Wayne Potts

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Category(s): Research Tools & Reagents, Screening Assays