Search Results - ivor+benjamin

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Assay for Determining Relative Redox Changes in Living Cells

Brief Description of the TechnologyThe current invention is a peptide construct that has been modified by fluorophores to monitor redox changes in live cells. The extent of fluorescence is dependent on the cellular GSH/GSSG ratio and is measured using a simple fluorescent plate reader. The technology has been validated with known redox active compounds....

Published: 5/7/2019 | Inventor(s): Shayne Squires, Ivor Benjamin

Keywords(s):

Category(s): Research Tools & Reagents, Screening Assays

Novel Anti-Reductive Strategies for the Treatment of Heart Failure, Diabetes Mellitus and Degenerative Diseases

Invention Summary: Though oxidative stress is widely implicated in pathogenic states including aging and heart failure, the role of reductive stress, which is defined as the abnormal increase of reducing equivalents (e.g., glutathione, NADPH), remains controversial. The present invention provides genetic, molecular, and biochemical evidence for...

Published: 8/4/2017 | Inventor(s): Ivor Benjamin, Rajasekaran Namakkal

Keywords(s):

Category(s): Cardiology, Therapeutics