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Novel Anti-Reductive Strategies for the Treatment of Heart Failure, Diabetes Mellitus and Degenerative Diseases

Invention Summary: Though oxidative stress is widely implicated in pathogenic states including aging and heart failure, the role of reductive stress, which is defined as the abnormal increase of reducing equivalents (e.g., glutathione, NADPH), remains controversial. The present invention provides genetic, molecular, and biochemical evidence for...

Published: 8/4/2017 | Inventor(s): Ivor Benjamin, Rajasekaran Namakkal

Keywords(s):

Category(s): Cardiology, Therapeutics