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Detecting Base-Pair Mismatches and Modifications in Polynucleotides through Base Flipping

Invention SummaryThis technology proposes a novel way of detecting localized conformational mutations in DNA, also known as single nucleotide polymorphisms (SNPs), through utilizing a protein nanopore alpha hemolysin. Using this technology, base pair mismatches can be identified by measuring local conformational changes in the DNA molecule, from which...

Published: 3/19/2019 | Inventor(s): Henry White, Cynthia Burrows, Robert Johnson, Aaron Fleming

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Category(s): Research Tools & Reagents