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Detecting Base-Pair Mismatches and Modifications in Polynucleotides through Base Flipping
Invention SummaryThis technology proposes a novel way of detecting localized conformational mutations in DNA, also known as single nucleotide polymorphisms (SNPs), through utilizing a protein nanopore alpha hemolysin. Using this technology, base pair mismatches can be identified by measuring local conformational changes in the DNA molecule, from which...
Published: 3/19/2019
|
Inventor(s):
Henry White
,
Cynthia Burrows
,
Robert Johnson
,
Aaron Fleming
Keywords(s):
Category(s):
Research Tools & Reagents
Preventing Non-Specific Adsorption of Proteins to Glass or Other Materials Through Surface Modification **Value Express**
Patent Abstract A method of preventing non-specific adsorption of proteins onto a surface can include providing a substrate that has a surface on which surface groups are attached. A solution can be applied to the surface that includes a protective reagent having a terminal functional group exhibiting a dipole moment. A monolayer comprising the...
Published: 4/13/2020
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Inventor(s):
Joel Harris
,
Henry White
,
Joshua Wayment
,
Ryan White
Keywords(s):
Chemicals
,
Coatings
Category(s):
Chemicals
,
Coatings
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