Search Results - non-cancer+disease+therapeutics

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Novel Anti-Inflammatory and/or Analgesic Agents

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Published: 8/14/2019 | Inventor(s): Joseph Michael McIntosh, Linda Dwoskin, Peter Crooks

Keywords(s): Non-Cancer Disease Therapeutics

Category(s): Therapeutics, Small Molecule

Method of T Lymphocyte Generation From Hematopoietic Stem Cells

Summary: This technology includes methods for the production of T lymphocytes and Cytotoxic (Natural Killer, or NK) lymphocytes from uncommitted hematopoietic stem/progenitor cells. It begins with undifferentiated hematopoetic stem cells, cultured under conditions which promote specification of the lymphocyte lineage. These cells subsequently...

Published: 5/2/2019 | Inventor(s): Gerald Spangrude, Birgitta Mitchell

Keywords(s): Cancer Diagnostics and Treatment, Non-Cancer Disease Therapeutics, Stem Cells

Category(s): Biotechnology, Proteomics

Penumbra Nucleic Acid Molecules, Proteins and Methods of Their Detection and Use, Especially for Myeloid (Bone Marrow) Diseases

Invention Description: This invention identifies the human Penumbra gene nucleic acid molecules, proteins encoded by these nucleic acid molecules, antibodies raised against these proteins, and inhibitors of these proteins. The invention also includes methods of using these molecules in the detection of disease, including human myeloid malignancies....

Published: 5/7/2019 | Inventor(s): Schickwann Tsai, Zhong Chen

Keywords(s): Non-Cancer Disease Therapeutics, Research Tools

Category(s): Research Tools & Reagents, Reagents

Methods for Treatment and Prevention of Acute Renal Failure and Multi-organ Failure

Invention Summary Acute Renal Failure (ARF), in the context of multi-organ failure and in high risk patients, remains a common, and often fatal (~50% mortality), complication. Preventative measures are only poorly effective, and dialysis therapy is expensive and time consuming. ARF is characterized by cell injury and death by necrosis and apoptosis...

Published: 7/17/2019 | Inventor(s): Christof Westenfelder

Keywords(s): Non-Cancer Disease Therapeutics

Category(s): Therapeutics, Drug Repurposing

Methods for In Vivo Stimulation of Erythropoietin Production

Summary: This invention discloses an approach whereby the administration of a synthetic organic compound specifically induces proliferation of erythropoietin-producing peritubular interstitial cells in the kidney, which results in increased synthesis of erythropoietin. After cessation of treatment with the synthetic compound, there is persistence...

Published: 10/1/2019 | Inventor(s): Bellamkonda Kishore, Jorge Isaac, Christof Westenfelder

Keywords(s): Biologics, Non-Cancer Disease Therapeutics, Therapeutics

Category(s): Therapeutics, Biologics

Novel Therapeutic Approaches for the Treatment of Acquired Nephrogenic Diabetes Insipidus

Summary: This invention discloses a novel set of interactions between the prostaglandin and purine signaling pathways that reveal a new class of drug targets for future NDI therapies. Market Applications: Nephrogenic Diabetes Insipidus (NDI) can be acquired as a result of the use of medicines such as lithium for bipolar disorders, or others such...

Published: 10/1/2019 | Inventor(s): Bellamkonda Kishore, Noel Carlson, Donald Kohan, Raoul Nelson

Keywords(s): Non-Cancer Disease Therapeutics, Small Molecule, Therapeutics

Category(s): Therapeutics, Small Molecule