Search Results - small+molecule

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Novel Irreversible Inhibitors of Bruton's Tyrosine Kinase (BTK)

Invention Summary Bruton’s Tyrosine Kinase (BTK) is a nonreceptor cytoplasmic tyrosine kinase, predominantly expressed in hematopoietic cells. Targeted inhibition of BTK is a validated therapeutic strategy for diseases caused by abnormal activation of B-cells, including cancers, and autoimmune and inflammatory diseases. Drug discovery efforts...

Published: 7/16/2019 | Inventor(s): David Bearss, Hariprasad Vankayalapati, Venkataswamy Sorna, Steven Warner, Sunil Sharma

Keywords(s):

Category(s): Therapeutics, Small Molecule

Drug Family With The Ability to Reactivate Latent HIV

Invention SummaryAlthough current therapies can reduce HIV to undetectable levels, latent HIV virus continues to persist in hidden reservoirs within resting memory T cells. Once a patient stops the antiretroviral regimen, the latent virus will rebound in a matter of weeks.University of Utah investigators have identified specific compounds which are...

Published: 5/7/2019 | Inventor(s): Vicente Planelles, Alberto Bosque Pardos, Chris Ireland, Ryan Van Wagoner, Mary Kay Harper-Ireland, John Alan Maschek

Keywords(s):

Category(s): Therapeutics, Small Molecule

Paclitaxel Trihydrate

Novel Paclitaxel Trihydrates University Reference Number: U-4987 Invention Summary University of Utah inventors discovered novel paclitaxel trihydrates. The paclitaxel trihydrates described in this technology are obtained by recrystallizing paclitaxel from a water/alcohol solution. As evidenced by NMR spectra, the novel paclitaxel trihydrates have...

Published: 3/18/2019 | Inventor(s): David Grant (deceased), James Harper, Robert Von Dreele

Keywords(s): Cancer Diagnostics and Treatment, Chemicals

Category(s): Therapeutics, Small Molecule

New Potent ß-Catenin/T-cell Factor Inhibitors

Invention Summary New potent inhibitors of the ß-catenin/T-cell factor (Tcf) interaction have been designed and synthesized by a University of Utah inventor. These new micro molar inhibitors are shown to bind to key ß-catenin binding sights and are effective at preventing the growth of cancer cells. Value Proposition • New potent inhibitors,...

Published: 10/21/2019 | Inventor(s): Haitao (mark) Ji, Binxun Yu, Min Zhang, Wenxing Guo

Keywords(s): Small Molecule, Therapeutics

Category(s): Therapeutics, Small Molecule

Isolation, Identification and Uses of Antifungal Compounds

TECHNOLOGY SUMMARY New antifungal peptides called Burkholdines Can be used to treat fungal infections in human subjectsCan help solve deadly fungal infections in plants and crops which are resistant to existing antifungal agentsBENEFITSBurkholdine compounds are more potent than existing antifungal agents16-60 times the potency of amphotericin control...

Published: 9/13/2019 | Inventor(s): Eric Schmidt, Peter Jeffs, Joseph Falkinham

Keywords(s): Small Molecule, Therapeutics

Category(s): Therapeutics, Small Molecule

Novel Anti-Inflammatory and/or Analgesic Agents

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Published: 8/14/2019 | Inventor(s): Joseph Michael McIntosh, Linda Dwoskin, Peter Crooks

Keywords(s): Non-Cancer Disease Therapeutics

Category(s): Therapeutics, Small Molecule

Novel Therapeutic Approaches for the Treatment of Acquired Nephrogenic Diabetes Insipidus

Summary: This invention discloses a novel set of interactions between the prostaglandin and purine signaling pathways that reveal a new class of drug targets for future NDI therapies. Market Applications: Nephrogenic Diabetes Insipidus (NDI) can be acquired as a result of the use of medicines such as lithium for bipolar disorders, or others such...

Published: 10/1/2019 | Inventor(s): Bellamkonda Kishore, Noel Carlson, Donald Kohan, Raoul Nelson

Keywords(s): Non-Cancer Disease Therapeutics, Small Molecule, Therapeutics

Category(s): Therapeutics, Small Molecule