Search Results - therapeutics

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HPMA-based active targeted polymer-anticancer drug conjugates

TECHNOLOGY SUMMARYDrug delivery Pioneer, Dr. Jindřich Kopeček has innovated the next generation of Antibody Drug Conjugates (ADC) with high efficacy tumor targeting and minimal off-target toxicity. The innovative approach involves a controlled living polymerization technique which results in a well-defined semitelechelic maleimide functionalized HPMA...

Published: 9/13/2019 | Inventor(s): Jiyuan Yang, Jindrich (henry) Kopecek, Libin Zhang, Yixin Fang

Keywords(s): Biologics, Therapeutics

Category(s): Therapeutics, Biologics

Novel Peptide for Intervention in Metabolic Syndrome and Obesity

TECHNOLOGY SUMMARYA novel peptide corrects a multitude of abnormalities associated with metabolic syndrome, including obesity, hyperglycemia, and insulin resistance, and is highly potent.BENEFITSNovel biologic agent for intervention in metabolic syndrome and obesity. MARKET OPPORTUNITY The global obesity treatment market is expected to reach USD 15.6...

Published: 4/3/2020 | Inventor(s): Tianxin Yang

Keywords(s): Biologics, Therapeutics

Category(s): Therapeutics, Biologics

BH4 (KUVAN) for Treatment of Systemic Sclerosis Vasculopathy

Invention SummarySystemic Sclerosis (SSc) SSc is a multisystem autoimmune disorder with a progressively devastating course. There is increased fibroblast activity resulting in abnormal growth of connective tissue causing vascular damage and fibrosis. Fibrosis occurs in skin, the gastrointestinal (GI) tract and other internal organs ;leading to digital...

Published: 9/13/2019 | Inventor(s): Anthony Donato, Tracy Frech

Keywords(s): Drug Repurposing, Therapeutics

Category(s): Therapeutics, Drug Repurposing

Naonparticle Antibody Conjugate Platform For Targeted Delivery and Tumor Killing

Invention SummaryMonoclonal antibody as a single agent therapy for solid and blood cancers show limited clinical efficacy. High doses are needed which result in undesired adverse immunogenicity and toxicity. Conjugating antibodies to cytotoxic drug show durable clinical response. However ADC designing is complex, with knowledge of linkers, drug and...

Published: 9/13/2019 | Inventor(s): Xinjian Chen, Chengke Luo

Keywords(s): Biologics, Therapeutics

Category(s): Therapeutics, Biologics

Novel Inhibitors of Inflammatory Injury Caused by Neutrophil Extracellular Traps (NETs)

Invention Summary The inventors have developed a novel means of inhibiting NET development and preventing further tissue injury associated with inflammation, both of which will decrease morbidity and mortality. While NET formation is a potent mechanism of killing microbes, there is emerging evidence that NETs mediate vascular and tissue injury in inflammatory...

Published: 9/13/2019 | Inventor(s): Christian Yost, Guy Zimmerman, Andrew Weyrich

Keywords(s): Biologics, Therapeutics

Category(s): Therapeutics, Biologics

New Therapeutic Strategy for Inhibition of Angiogenesis and Lymphangiogenesis Using Targeted Morpholinos

Invention Summary The invention presents a new strategy for inhibition of angiogenesis and lymphangiogenesis through manipulation of VEGFR isoform expression. The VEGFR1 and VEGFR2 genes produce both membrane-bound and soluble isoforms, which have differing effects on these processes. The membrane bound isoforms promote angiogenesis, while...

Published: 3/5/2020 | Inventor(s): Bala Ambati, Hironori Uehara

Keywords(s): Gene Therapy, Silencing & Editing, Therapeutics

Category(s): Therapeutics, Therapeutics, Gene Therapy, Silencing & Editing

New Potent ß-Catenin/T-cell Factor Inhibitors

Invention Summary New potent inhibitors of the ß-catenin/T-cell factor (Tcf) interaction have been designed and synthesized by a University of Utah inventor. These new micro molar inhibitors are shown to bind to key ß-catenin binding sights and are effective at preventing the growth of cancer cells. Value Proposition • New potent inhibitors,...

Published: 10/21/2019 | Inventor(s): Haitao (mark) Ji, Binxun Yu, Min Zhang, Wenxing Guo

Keywords(s): Small Molecule, Therapeutics

Category(s): Therapeutics, Small Molecule

Isolation, Identification and Uses of Antifungal Compounds

TECHNOLOGY SUMMARY New antifungal peptides called Burkholdines Can be used to treat fungal infections in human subjectsCan help solve deadly fungal infections in plants and crops which are resistant to existing antifungal agentsBENEFITSBurkholdine compounds are more potent than existing antifungal agents16-60 times the potency of amphotericin control...

Published: 9/13/2019 | Inventor(s): Eric Schmidt, Peter Jeffs, Joseph Falkinham

Keywords(s): Small Molecule, Therapeutics

Category(s): Therapeutics, Small Molecule

Tumor Environment Induced Ligand Expressing Nanocarrier System

Invention Description: Cancer cells are often characterized by specific antigens or overexpressed receptors on cell surfaces. Such receptors provide uptake routes for nutrients and signals from the surrounding environment, essential for active growth of the cells. These processes have now been utilized as an important delivery mode for macromolecular...

Published: 10/8/2019 | Inventor(s): You Han Bae, Kun Na, Eun Seong Lee

Keywords(s): Cancer Diagnostics and Treatment, Drug Delivery, Medical Devices, Nanotechnology, Research Tools, Therapeutics

Category(s): Therapeutics, Drug Delivery

Methods for In Vivo Stimulation of Erythropoietin Production

Summary: This invention discloses an approach whereby the administration of a synthetic organic compound specifically induces proliferation of erythropoietin-producing peritubular interstitial cells in the kidney, which results in increased synthesis of erythropoietin. After cessation of treatment with the synthetic compound, there is persistence...

Published: 10/1/2019 | Inventor(s): Bellamkonda Kishore, Jorge Isaac, Christof Westenfelder

Keywords(s): Biologics, Non-Cancer Disease Therapeutics, Therapeutics

Category(s): Therapeutics, Biologics

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