Search Results - gene+therapy%2c+silencing+%26+editing

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New Therapeutic Strategy for Inhibition of Angiogenesis and Lymphangiogenesis Using Targeted Morpholinos

Invention Summary The invention presents a new strategy for inhibition of angiogenesis and lymphangiogenesis through manipulation of VEGFR isoform expression. The VEGFR1 and VEGFR2 genes produce both membrane-bound and soluble isoforms, which have differing effects on these processes. The membrane bound isoforms promote angiogenesis, while...

Published: 3/5/2020 | Inventor(s): Bala Ambati, Hironori Uehara

Keywords(s): Gene Therapy, Silencing & Editing, Therapeutics

Category(s): Therapeutics, Therapeutics, Gene Therapy, Silencing & Editing

Novel Therapeutic Strategy for Preserving Vision

Technology DescriptionIn the healthy eye, regulation of blood vessel growth, or angiogenesis, is critical for visual clarity. Dysregulated angiogenesis is the cause of vision loss and blindness associated with age-related macular degeneration, diabetic retinopathy, neovascular glaucoma, and corneal neovascularization. The Raver2 protein has been identified...

Published: 8/18/2017 | Inventor(s): Balamurali Ambati, Derick Holt

Keywords(s):

Category(s): Ophthalmology, Gene Therapy, Silencing & Editing, Therapeutics, Therapeutics

Peptide - Polymer Complex Delivers Nucleic Acid to the Artery Wall **Value Express**

Patent Abstract An artery wall binding peptide (AWBP) based on the artery wall cell-binding domain of apolipoprotein B-100 was conjugated to a cationic backbone configured for forming a complex with a nucleic acid to produce a composition that enhances gene transfer to artery wall cells. An illustrative cationic backbone is poly(ethylene glycol)-grafted-poly(L-lysine)...

Published: 7/19/2019 | Inventor(s): Sung Wan Kim, Lei Yu, Jae-Woon Nah

Keywords(s):

Category(s): Therapeutics, Gene Therapy, Silencing & Editing, Research Tools & Reagents