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Peptide - Polymer Complex Delivers Nucleic Acid to the Artery Wall **Value Express**
Patent Abstract An artery wall binding peptide (AWBP) based on the artery wall cell-binding domain of apolipoprotein B-100 was conjugated to a cationic backbone configured for forming a complex with a nucleic acid to produce a composition that enhances gene transfer to artery wall cells. An illustrative cationic backbone is poly(ethylene glycol)-grafted-poly(L-lysine)...
Published: 7/19/2019
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Inventor(s):
Sung Wan Kim
,
Lei Yu
,
Jae-Woon Nah
Keywords(s):
Category(s):
Therapeutics
,
Gene Therapy, Silencing & Editing
,
Research Tools & Reagents
Cholesterol and Oligoarginine Complex for siRNA Delivery
Agent Delivered / Target: siRNA / endocytosis capitalizing on cholesterol and cell-penetrating peptides Chemical Composition: Cholesterol oligo-D-arginine (Chol-R9) Physical Composition: Complexes of siRNA and Chol-R9 Intellectual Property / Development: US patent 7,740,880 issued / in vivo in mice
Published: 10/1/2019
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Inventor(s):
Won Jong Kim
,
Sung Wan Kim
Keywords(s):
Cancer Diagnostics and Treatment
,
Cell Lines
,
Medical Devices
,
Research Tools & Reagents
Category(s):
Research Tools & Reagents
,
Cell Lines
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