Search Results - drug+delivery

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Methods to Treat Dry Mouth in Sjögren’s Syndrome

Invention SummarySjögren’s syndrome is an autoimmune disease that affects the entire body. The most common symptoms include dry eyes and dry mouth which causes pain for the patient and can make it difficult to swallow or speak. Sjögren’s syndrome is one of the most dominant autoimmune diseases, with upwards of 4 million American’s...

Published: 5/7/2019 | Inventor(s): Olga Baker, Kihoon Nam, Pedro Lei, Stelios Andreadis

Keywords(s):

Category(s): Therapeutics, Drug Delivery

Nanoparticles to Orally Deliver Injectable Therapeutics

Invention SummaryThe technology makes nanoparticles orally available by utilizing the enterohepatic circulation pathway of bile acids in the epithelium of the distal ileum. The nanoparticles can carry various payloads of genetic materials such as, plasmid DNA (encoding particular proteins), active proteins/peptides (e.g., insulin), and small molecules...

Published: 5/7/2019 | Inventor(s): You Han Bae, Yong-Kyu Lee, Md Nurunnabi

Keywords(s):

Category(s): Therapeutics, Drug Delivery

Modified Release Osmotic Pump for pH Responsive Intravaginal Drug Delivery

Invention SummaryAn intravaginal osmotic tablet which can deliver pharmaceutical agents for 3-7 days following insertion into the vaginal lumen. Upon changes in pH, such as during coitus, the shell of the tablet bursts and releases the total remaining drug load into the vaginal tract.Value PropositionControlled release maintains appropriate therapeutic...

Published: 9/26/2017 | Inventor(s): Patrick Kiser, Rachna Rastogi

Keywords(s):

Category(s): Therapeutics, Drug Delivery, Medical Devices

Radiation Enhanced Macromolecular Delivery of Therapeutic Agents for Chemotherapy

Invention Description: This invention aims to develop novel polymeric delivery systems that significantly enhance the therapeutic index of cancer chemotherapy. Water soluble macromolecules are conjugated to dual anticancer drugs that have unmet clinical needs such as acquired drug resistance, toxicity or poor solubility. The polymer conjugates of...

Published: 7/11/2019 | Inventor(s): Abhijit Ray, Hamidreza Ghandehari

Keywords(s):

Category(s): Oncology, Drug Delivery, Radiology, Therapeutics

Tumor Environment Induced Ligand Expressing Nanocarrier System

Invention Description: Cancer cells are often characterized by specific antigens or overexpressed receptors on cell surfaces. Such receptors provide uptake routes for nutrients and signals from the surrounding environment, essential for active growth of the cells. These processes have now been utilized as an important delivery mode for macromolecular...

Published: 10/8/2019 | Inventor(s): You Han Bae, Kun Na, Eun Seong Lee

Keywords(s): Cancer Diagnostics and Treatment, Drug Delivery, Medical Devices, Nanotechnology, Research Tools, Therapeutics

Category(s): Therapeutics, Drug Delivery

Targeted Combination Drug Delivery and Photothermal Therapy for the Treatment of Cancer (this can be potentially used for other diseases as well)

Invention Description: Gold nanorods have great potential to treat cancer by photothermal therapy. Local heat generated by high energy laser excitation of their surface plasmons has the capacity to kill malignancies by photothermal lysis of nearby cancerous cells. Unfortunately, limited tissue penetration depths of light may ultimately limit the...

Published: 6/6/2019 | Inventor(s): Hamidreza Ghandehari, Adam Gormley, Abhijit Ray

Keywords(s):

Category(s): Drug Delivery, Platform Method, Therapeutics, Radiology