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HPMA-based active targeted polymer-anticancer drug conjugates

TECHNOLOGY SUMMARYDrug delivery Pioneer, Dr. Jindřich Kopeček has innovated the next generation of Antibody Drug Conjugates (ADC) with high efficacy tumor targeting and minimal off-target toxicity. The innovative approach involves a controlled living polymerization technique which results in a well-defined semitelechelic maleimide functionalized HPMA...

Published: 9/13/2019 | Inventor(s): Jiyuan Yang, Jindrich (henry) Kopecek, Libin Zhang, Yixin Fang

Keywords(s): Biologics, Therapeutics

Category(s): Therapeutics, Biologics

Hybridization Mediated Drug Free Macromolecular Therapeutics

Technology Description90% of all non-Hodgkin’s lymphomas (NHL) express CD20. Dr. Kopecek’s team has developed a novel, polymer-based, targeted drug-free therapy. The cytotoxic mechanism of action is via molecular cues that are triggered in the targeted cell (apoptosis). This new paradigm therapy leads to eradication of the tumor and will result...

Published: 5/7/2019 | Inventor(s): Jindrich (henry) Kopecek, Jiyuan Yang, Te-Wei Chu

Keywords(s):

Category(s): Therapeutics, Biologics