Search Results - diagnostics

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GEMINI

Invention SummaryGEMINI (GEnome MINIng) is a flexible online framework used to explore genetic variation in the context of genome annotations available for the human genome. By placing genetic variants, sample phenotypes and genotypes, as well as genome annotations into an integrated database framework, GEMINI provides a simple, flexible, and powerful...

Published: 9/13/2019 | Inventor(s): Aaron Quinlan, Brent Pedersen

Keywords(s): Diagnostics, Software

Category(s): Diagnostics, Software

Improved Analysis of ChIP-Based Data Sets

Invention SummaryA new technology has been developed which is an augment to ChIP based methods of mapping protein bonding sites on the genome. This technology provides an input control for ChIP-based protocols, such as ChIP-exo, that offers improved artifact reduction in data and a statistically valid control sample when performing extensive sample...

Published: 9/13/2019 | Inventor(s): Bethany Buck-Koehntop, Tommy Terooatea, Amir Pozner

Keywords(s): Diagnostics, Instrumentation

Category(s): Diagnostics, Instrumentation

Ultra-Fast PCR Microchip with Real Time Melting Analysis

Invention SummaryThe present invention provides a device capable of performing polymerase chain reaction (PCR) in less time than the fastest commercial PCR thermocyclers. It is achieved with high purity and minimal reduction in amplification efficiency. This device is capable of performing real-time measure of both the bulk fluorescence and the melting...

Published: 2/19/2020 | Inventor(s): Bruce Gale, Niel Crews, Carl Wittwer

Keywords(s): Diagnostics, Instrumentation

Category(s): Diagnostics, Instrumentation

Novel Primer Design for Quantitative Allele-Specific PCR

Invention SummaryThis invention provides a novel primer design, incorporating site-specific mismatches and locked nucleic acids, for real-time quantitative allele-specific PCR (AS-PCR), resulting in improved sensitivity, specificity and reproducibility of detection. This method provides greatly improved quantitation of low-level polymorphisms and alleles,...

Published: 1/29/2020 | Inventor(s): Josef Prchal, Roberto Nussenzweig, Sabina Swierczek

Keywords(s): Diagnostics, Molecular, Nucleic Acid Diagnostics

Category(s): Diagnostics, Molecular